Ayaz A, Alwan Y, Farooq M U
Hera General Hospital, Makkah, Saudi Arabia.
J Med Life. 2013 Jun 15;6(2):199-201. Epub 2013 Jun 25.
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women and is associated with the reproductive and metabolic disorders.
To compare the ovulation and conception rates after the treatment with Clomiphene Citrate (CC) alone and in combination with metformin in infertile patients presented with polycystic ovarian syndrome (PCOS).
MATERIAL & METHODS: This randomized controlled trial of independent cases and controls was conducted in the Department of Obstetrics and Gynecology, Hera General Hospital, Makkah, Saudi Arabia, during 2008. The 42 subjects diagnosed as PCOS were divided into group A and B (21 subjects in each) for the management with CC + metformin and CC alone, respectively. Group A received 500mg of metformin continuously, three times a day from the first cycle, for 6 months or until the pregnancy was confirmed. In both groups, CC was started with a dose of 50 mg from day-2 until day-6 of the menstrual cycle. The dose of CC was increased to 100 mg in the second and 150 mg in the third cycle, and then 150 mg remained for the rest of three cycles. With ovulation, the dose of CC was unaltered in both groups. Data were analyzed by using SPSS version 16.
More than 50% of the females in both groups had a body mass index of >25. Group A achieved a higher rate of regular cycles, ovulation success, and conception than group B (71.4% vs. 38.1%; p=0.03), (76.2% vs. 38.1%; p=0.021) and (66.6% vs. 28.6%, p=0.01), respectively.
Management with metformin + CC increased the ovulation and conception rates.
多囊卵巢综合征（PCOS）是女性中最常见的内分泌疾病，与生殖和代谢紊乱相关。
比较单独使用枸橼酸氯米芬（CC）以及联合二甲双胍治疗多囊卵巢综合征（PCOS）不孕患者后的排卵率和受孕率。
本独立病例与对照的随机对照试验于2008年在沙特阿拉伯麦加赫拉综合医院妇产科进行。42例被诊断为PCOS的受试者分别分为A组和B组（每组21例），分别采用CC + 二甲双胍和单独使用CC进行治疗。A组从第一个周期开始，每天三次连续服用500mg二甲双胍，共6个月或直至确认怀孕。两组均在月经周期的第2天至第6天开始使用剂量为50mg的CC。在第二个周期，CC剂量增加至100mg，第三个周期增加至150mg，然后在剩余的三个周期中维持150mg。出现排卵后，两组CC剂量均不变。使用SPSS 16版软件进行数据分析。
两组中超过50%的女性体重指数>25。A组在规律月经周期率、排卵成功率和受孕率方面均高于B组（分别为71.4%对38.1%；p = 0.03），（76.2%对38.1%；p = 0.021）和（66.6%对28.6%，p = 0.01）。
二甲双胍 + CC治疗可提高排卵率和受孕率。
