Connor D J, Harrell L E, Jope R S
University of Alabama, Birmingham.
Behav Neurosci. 1989 Aug;103(4):779-83. doi: 10.1037//0735-7044.103.4.779.
Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for 30 days resulted in a reduction in the number of days to reach extinction criterion on a passive avoidance task (38% control level). The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Partial reversal of the deficit was produced by discontinuing aluminum treatment 2 weeks prior to testing (p less than .05). Injection of the aluminum chelator deferoxamine returned the performance of the aluminum-treated animals to control levels in a dose-dependent manner but had no effect on control animals. No differences in open-field activity were evident across groups. These results indicate that the behavioral impairment is a specific, reversible, toxic effect of the aluminum administration.
给雄性斯普拉格-道利大鼠的饮用水中添加硫酸铝30天，结果显示在被动回避任务中达到消退标准所需的天数减少（为对照组水平的38%）。行为缺陷并非因液体摄入量减少导致的非特异性影响所致。在测试前2周停止铝处理可使缺陷部分逆转（p小于0.05）。注射铝螯合剂去铁胺可使经铝处理的动物的表现以剂量依赖的方式恢复到对照组水平，但对对照动物没有影响。各组之间在旷场活动方面没有明显差异。这些结果表明，行为损伤是铝给药的一种特异性、可逆的毒性作用。
