慢性淋巴细胞白血病的突变图谱及潜在突变过程
Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia.
作者信息
Kasar S, Brown J R
机构信息
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Mol Cell Oncol. 2016 Mar 10;3(4):e1157667. doi: 10.1080/23723556.2016.1157667. eCollection 2016 Jul.
Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes-2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature-that operate at different times throughout CLL evolution.
测序研究在理解慢性淋巴细胞白血病（CLL）的遗传基础方面发挥了重要作用。我们最近针对低细胞遗传学风险CLL的全基因组测序研究表明，CLL突变可归因于3个关键的突变过程——2种激活诱导胞嘧啶脱氨酶（AID）特征和一种衰老特征，这些过程在CLL整个病程的不同时间发挥作用。
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