高迁移率族蛋白B1：自然杀伤细胞武器库中的代谢武器。
HMGB1: The metabolic weapon in the arsenal of NK cells.
作者信息
Cerwenka Adelheid, Kopitz Jürgen, Schirmacher Peter, Roth Wilfried, Gdynia Georg
机构信息
German Cancer Research Center, Research Group Innate Immunity , Heidelberg, Germany.
Institute of Pathology, University of Heidelberg , Heidelberg, Germany.
出版信息
Mol Cell Oncol. 2016 Apr 15;3(4):e1175538. doi: 10.1080/23723556.2016.1175538. eCollection 2016 Jul.
Abstract
Targeting tumor glycolysis would hit the main energy source of cancer. We show that natural killer (NK) cells pursue this strategy by employing high mobility group box 1 (HMGB1) protein-a well-known proinflammatory cytokine-to specifically target glycolysis in cancer cells. This opens up new perspectives for cancer immunotherapy.
摘要
靶向肿瘤糖酵解将直击癌症的主要能量来源。我们发现，自然杀伤（NK）细胞通过利用高迁移率族蛋白B1（HMGB1）——一种众所周知的促炎细胞因子——来特异性靶向癌细胞中的糖酵解，从而采用了这一策略。这为癌症免疫治疗开辟了新的前景。
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