囊泡运输调节因子是乳腺癌进展中的新角色：TOM1L1在ERBB2依赖性侵袭中的作用
Vesicular trafficking regulators are new players in breast cancer progression: Role of TOM1L1 in ERBB2-dependent invasion.
作者信息
Chevalier Clément, Roche Serge, Bénistant Christine
机构信息
Centre de Recherche de Biologie Cellulaire de Montpellier, Equipe labellisée Ligue Contre le Cancer, CNRS UMR 5237 , Montpellier, France.
Centre de Recherche de Biologie Cellulaire de Montpellier, Equipe labellisée Ligue Contre le Cancer, CNRS UMR 5237, Montpellier, France; Centre de Biochimie Structurale, CNRS UMR 5048-INSERM UMR 1054, Montpellier, France.
出版信息
Mol Cell Oncol. 2016 Apr 28;3(4):e1182241. doi: 10.1080/23723556.2016.1182241. eCollection 2016 Jul.
Abstract
ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) amplification is associated with invasive breast cancer. We discovered that TOM1L1 (target of myb1-like 1) and ERBB2 co-amplification defines a novel mechanism involved in breast cancer metastatic progression. Upregulation of the vesicular trafficking protein TOM1L1 enhances plasma membrane delivery of membrane-type 1 matrix metalloprotease (MT1-MMP) for efficient extracellular matrix degradation and tumor cell dissemination.
摘要
ERBB2（v-erb-b2禽成红细胞白血病病毒癌基因同源物2）扩增与浸润性乳腺癌相关。我们发现TOM1L1（类Myb1靶点1）与ERBB2共同扩增定义了一种参与乳腺癌转移进展的新机制。囊泡运输蛋白TOM1L1的上调增强了膜型1基质金属蛋白酶（MT1-MMP）向质膜的转运，从而有效地降解细胞外基质并促进肿瘤细胞播散。
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