Department of Pathology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Pathology, University Emergency Hospital, 050098 Bucharest, Romania.
Int J Mol Sci. 2023 Sep 14;24(18):14073. doi: 10.3390/ijms241814073.
Breast cancer represents a paramount global health challenge, warranting intensified exploration of the molecular underpinnings influencing its progression to facilitate the development of precise diagnostic instruments and customized therapeutic regimens. Historically, the Golgi apparatus has been acknowledged for its primary role in protein sorting and trafficking within cellular contexts. However, recent findings suggest a potential link between modifications in Golgi apparatus function and organization and the pathogenesis of breast cancer. This review delivers an exhaustive analysis of this correlation. Specifically, we examine the consequences of disrupted protein glycosylation, compromised protein transport, and inappropriate oncoprotein processing on breast cancer cell dynamics. Furthermore, we delve into the impacts of Golgi-mediated secretory routes on the release of pro-tumorigenic factors during the course of breast cancer evolution. Elucidating the nuanced interplay between the Golgi apparatus and breast cancer can pave the way for innovative therapeutic interventions and the discovery of biomarkers, potentially enhancing the diagnostic, prognostic, and therapeutic paradigms for afflicted patients. The advancement of such research could substantially expedite the realization of these objectives.
乳腺癌是一项全球性的重大健康挑战，需要深入研究影响其进展的分子基础，以促进精确诊断仪器和个体化治疗方案的开发。历史上，高尔基体在细胞内的蛋白质分拣和运输中起着主要作用。然而，最近的研究结果表明，高尔基体功能和结构的改变与乳腺癌的发病机制之间存在潜在联系。本综述对这种相关性进行了全面的分析。具体来说，我们研究了蛋白质糖基化、蛋白质运输受损以及异常致癌蛋白加工对乳腺癌细胞动力学的影响。此外，我们还探讨了高尔基体介导的分泌途径在乳腺癌演变过程中释放促肿瘤因子的影响。阐明高尔基体与乳腺癌之间的细微相互作用，可以为创新的治疗干预措施和生物标志物的发现铺平道路，从而有可能提高患者的诊断、预后和治疗水平。推进这方面的研究可以大大加快实现这些目标的速度。
