Luo Hong-Dou, Jin Mei-Ying, Wu Hui, Jiang Hui
Hangzhou Zhongmei Huadong Pharmaceutical Co., LTD, Hangzhou, Zhejiang 310011, China.
College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Protein Pept Lett. 2016;23(11):1032-1037. doi: 10.2174/0929866523666160920095131.
Many polyketides show biological activities and have thus been applied in clinics, as food additives, and in agriculture. Type II thioesterases (TEIIs) play an important role in polyketide biosynthesis. Most TEIIs belong to α/β-hydrolase family and usually contain a catalytic triad Ser-His-Asp. In polyketide biosynthesis, TEIIs can play an editing role by removal of aberrant non-extendable acyl units in elongation steps, a starter unit selection role by removal of unfavored starter acyl units in initiation steps, and a releasing role by removal of final product in termination steps. Complementation of TEIIs has been observed and applied.
许多聚酮化合物具有生物活性，因此已被应用于临床、作为食品添加剂以及用于农业。II型硫酯酶（TEIIs）在聚酮化合物生物合成中起重要作用。大多数TEIIs属于α/β-水解酶家族，通常含有催化三联体Ser-His-Asp。在聚酮化合物生物合成中，TEIIs可以通过在延伸步骤中去除异常的不可延伸酰基单元发挥编辑作用，通过在起始步骤中去除不合适的起始酰基单元发挥起始单元选择作用，并通过在终止步骤中去除最终产物发挥释放作用。已观察到并应用了TEIIs的互补作用。
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