McKnight A, Mannell A, Shperling I
Department of Nuclear Medicine, Witwatersrand University Medical School, Johannesburg, South Africa.
Br J Cancer. 1989 Aug;60(2):249-51. doi: 10.1038/bjc.1989.263.
Carcinoma of the oesophagus is endemic in certain well demarcated areas throughout the world, and a method of screening population groups at high risk for oesophageal cancer is urgently needed. In this study the sensitivity and specificity of the carbohydrate antigen CA19-9 as a marker of carcinoma of the oesophagus in African patients was examined. The normal range was established by assay of serum samples from healthy black blood donors, using a solid phase radioimmunoassay with mouse monoclonal antibody to CA19-9 labelled with 125I. Serum concentrations of CA19-9 were then measured in 100 African patients with oesophageal cancer and 28 patients with benign oesophageal disease. The upper limit of CA19-9 in the normal controls was 40 U ml-1. Thirty-four patients with oesophageal cancer and five with benign oesophageal disease had elevated levels. Therefore, in this series, the sensitivity of CA19-9 as a marker of oesophageal cancer was 34% and the specificity was 82%. While CA19-9 is not sufficiently sensitive to be used as a screening test of oesophageal cancer, it compares favourably with other known tumour markers of this disease, and may have a role in monitoring disease recurrence and response to treatment.
食管癌在世界上某些界限分明的地区呈地方性流行，因此迫切需要一种对食管癌高危人群进行筛查的方法。在本研究中，对糖类抗原CA19 - 9作为非洲患者食管癌标志物的敏感性和特异性进行了检测。通过使用用125I标记的抗CA19 - 9小鼠单克隆抗体的固相放射免疫分析法，对健康黑人献血者的血清样本进行检测，从而确定正常范围。然后对100例非洲食管癌患者和28例食管良性疾病患者的血清CA19 - 9浓度进行了测量。正常对照组中CA19 - 9的上限为40 U/ml。34例食管癌患者和5例食管良性疾病患者的CA19 - 9水平升高。因此，在该系列研究中，CA19 - 9作为食管癌标志物的敏感性为34%，特异性为82%。虽然CA19 - 9作为食管癌筛查试验的敏感性不够高，但与该疾病的其他已知肿瘤标志物相比具有优势，并且可能在监测疾病复发和治疗反应方面发挥作用。
