Patton D L, Kuo C C, Brenner R M
Department of Obstetrics and Gynecology, University of Washington, Seattle.
Br J Exp Pathol. 1989 Jun;70(3):357-67.
The subcutaneous pocket model of salpingeal, endometrial, and conjunctival autografts for studying Chlamydia trachomatis infection in monkeys is described. Portions of the salpinx that were transplanted included fimbria, ampulla, and isthmus. The model is an extension of the original model which consists of either salpingeal fimbria or conjunctive autografts. Transplantation of the ampulla portion of the Fallopian tube enabled us to increase the number of pockets or test sites. Salpingeal and conjunctival autografts could be established during a single surgery. In addition, it is possible to autotransplant endometrium and provoke endometritis. The autografts were shown to be susceptible to C. trachomatis infection. Preliminary rechallenge experiments showed infection of the subcutaneous transplants may induce immunity, indicating the model may be used for immunity and vaccine studies. Simultaneous transplantation of different parts of the oviduct, endometrium, and conjunctive should expand the usefulness of the subcutaneous model in other studies on mixed infections or immune responses to infection.
本文描述了用于研究猴沙眼衣原体感染的输卵管、子宫内膜和结膜自体移植的皮下袋模型。移植的输卵管部分包括伞端、壶腹部和峡部。该模型是原始模型的扩展，原始模型由输卵管伞端或结膜自体移植组成。输卵管壶腹部的移植使我们能够增加袋或试验部位的数量。输卵管和结膜自体移植可在一次手术中完成。此外，自体移植子宫内膜并引发子宫内膜炎是可能的。已证明自体移植物易受沙眼衣原体感染。初步的再激发实验表明，皮下移植物的感染可能诱导免疫，这表明该模型可用于免疫和疫苗研究。同时移植输卵管、子宫内膜和结膜的不同部位应能扩大皮下模型在其他混合感染或感染免疫反应研究中的用途。
