Kwon O, Cho S Y, Paick J-S, Kim S W
Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
Department of Urology, Seoul National University, College of Medicine, Seoul, Korea.
Int J Impot Res. 2017 Jan;29(1):23-29. doi: 10.1038/ijir.2016.39. Epub 2016 Sep 22.
Diabetes-induced ED correlates with diabetes duration and glycemic control. This study evaluated the effect of glycemic control start time on erectile function in streptozotocin-induced diabetic rats. Rats were divided into normal controls (C); untreated diabetic rats (DM); and rats treated after 7 weeks (7W), and 10 weeks (10W) from DM. Treated diabetic rats received a timed daily injection of insulin. After 14 weeks of lab-controlled diabetes, experiments were performed. Group DM showed the ratio of intracavernosal pressure, significantly lower than other groups (10W vs DM; P<0.001). Groups 7W and 10W responded similarly, but did not recover to normal level (group C vs 7W; P<0.001). The percentage of α-smooth muscle actin increased more with earlier start times, and group DM's percentages decreased significantly (group 10W vs DM; P<0.001). Apoptosis recovered significantly only in group 7W, comparable to group C. As start times became earlier, for all molecules (eNOS, Akt, MYPT1 and PECAM-1), treatment groups' results neared those of group C. In conclusion, erectile function of diabetic rats recovered closer to normal controls if diabetic treatment started earlier. And the level of glycemic control was expected to be more important than the start time of diabetic treatment.
糖尿病所致勃起功能障碍与糖尿病病程及血糖控制相关。本研究评估了血糖控制起始时间对链脲佐菌素诱导的糖尿病大鼠勃起功能的影响。大鼠被分为正常对照组（C）；未治疗的糖尿病大鼠（DM）；以及糖尿病发生7周（7W）和10周（10W）后接受治疗的大鼠。接受治疗的糖尿病大鼠每日定时注射胰岛素。在实验室控制糖尿病14周后进行实验。DM组阴茎海绵体内压比值显著低于其他组（10W组与DM组比较；P<0.001）。7W组和10W组反应相似，但未恢复到正常水平（C组与7W组比较；P<0.001）。α-平滑肌肌动蛋白的百分比随起始时间越早增加越多，DM组的百分比显著降低（10W组与DM组比较；P<0.001）。仅7W组的细胞凋亡显著恢复，与C组相当。随着起始时间越早，对于所有分子（内皮型一氧化氮合酶、蛋白激酶B、肌球蛋白磷酸酶靶向亚基1和血小板内皮细胞黏附分子-1），治疗组的结果越接近C组。总之，如果糖尿病治疗开始得越早，糖尿病大鼠的勃起功能恢复得越接近正常对照组。并且预计血糖控制水平比糖尿病治疗的起始时间更重要。
