Steinberg-Barkon Guy, Leibovitch Leah, Schushan-Eisen Irit, Gindes Liat, Strauss Tzipora, Maayan-Metzger Ayala
Sackler Faculty of Medicine, Department of Pediatrics, Tel Aviv University, Tel Aviv, Israel.
Department of Obstetrics, Sheba Medical Center, Tel HaShomer, Israel.
Am J Perinatol. 2017 Apr;34(5):465-470. doi: 10.1055/s-0036-1593348. Epub 2016 Sep 21.
Measuring fetal abdominal circumference (AC) prenatally is an effective tool for predicting neonatal weight and macrosomia. Data are lacking regarding the outcome of newborn infants with prenatal diagnosis of large AC. The aim of this study was to evaluate early short-term neonatal outcome among term singleton newborn infants with prenatal diagnosis of large AC. Retrospective data were collected on 501 term infants with prenatal diagnosis of large AC (≥ 360 mm) and on matched controls, including information on maternal condition and on infant perinatal complications. In compare with controls, the study group had higher incidence of macrosomia (188 [37.5%] vs. 18 [3.6%], < 0.001), hypoglycemia (48 (9.6%) vs. 25 [5%], = 0.007), and significant morbidity (49 [9.8%] vs. 28 [5.6%], = 0.017) but without increased incidence of congenital malformations or other perinatal complications. Only among the macrosomic, study subgroup and their controls differences were recorded including hypoglycemia (17.6 vs. 4.8%, < 0.001), need for oral glucose (11.2 vs. 2.7%, = 0.002), significant morbidity (10.1 vs. 3.7%, = 0.024), and hospitalization in special care unit (11.7 vs. 4.3%, = 0.012). Prelabor diagnosis of large AC mostly reflects the infant's high birth weight and macrosomia with the associated perinatal complications. Large AC by itself was not predictive of any congenital malformations or perinatal and postnatal complications.
产前测量胎儿腹围（AC）是预测新生儿体重和巨大儿的有效工具。目前缺乏关于产前诊断为大AC的新生儿结局的数据。本研究的目的是评估产前诊断为大AC的足月单胎新生儿的早期短期结局。收集了501例产前诊断为大AC（≥360mm）的足月婴儿及其匹配对照的回顾性数据，包括母亲情况和婴儿围产期并发症信息。与对照组相比，研究组巨大儿发生率更高（188例[37.5%]对18例[3.6%]，P<0.001）、低血糖发生率更高（48例[9.6%]对25例[5%]，P=0.007）以及显著发病率更高（49例[9.8%]对28例[5.6%]，P=0.017），但先天性畸形或其他围产期并发症的发生率没有增加。仅在巨大儿研究亚组及其对照组之间记录到差异，包括低血糖（17.6%对4.8%，P<0.001）、口服葡萄糖需求（11.2%对2.7%，P=0.002）、显著发病率（10.1%对3.7%，P=0.024）以及特殊护理病房住院率（11.7%对4.3%，P=0.012）。产程前诊断为大AC主要反映婴儿的高出生体重和巨大儿以及相关的围产期并发症。大AC本身并不能预测任何先天性畸形或围产期及产后并发症。
