Cancer Discov. 2016 Nov;6(11):1201. doi: 10.1158/2159-8290.CD-NB2016-116. Epub 2016 Sep 21.
In a study of patients with metastatic melanoma, researchers reported that higher numbers of cytotoxic T cells positive for both PD-1 and CTLA-4 in the tumor predicted response to anti-PD-1 therapy and improved progression-free survival.
在一项转移性黑色素瘤患者的研究中，研究人员报告称，肿瘤中 PD-1 和 CTLA-4 均阳性的细胞毒性 T 细胞数量较多，预示着对抗 PD-1 治疗有反应，并改善了无进展生存期。
