Liu B H, Sun M X, Zhou N, Li Y P, Wang M Z, Yu J, Zhou H S
Respiratory Internal Medicine Department, Dongying Peoples Hospital of Shandong provincial Hospital Group, Dongying, Shandong, China.
Tuberculosis Internal Medicine Department, Shandong Chest Hospital, Shangdong, China.
J Biol Regul Homeost Agents. 2016 Jul-Sep;30(3):839-845.
The purpose of this study was to observe the change in plasma D-dimer of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The patients were divided into three groups, i.e., AECOPD group, stable COPD group (COPD kept stable after treatment) and a healthy control group. The content of plasma fibrinogen (FIB) and D-dimer of all research subjects was detected and the difference between groups was analyzed. Moreover, pulmonary functions of patients in the AECOPD group and the stable COPD group, including forced expiratory volume in 1 second (FEV1%) and forced vital capacity rate of 1 second (FEV1/FVC), and blood gas (oxygen partial pressure (PO) and partial pressure of carbon dioxide (PaCO), were detected; and the differences between the two groups and the possible correlation were analyzed. Compared to the COPD stable group and the control group, the AECOPD group had a statistically significant higher content of plasma FIB and D-dimer (p less than 0.05); the content of plasma FIB and D-dimer of the COPD stable group was much higher than that of the healthy control group, but the difference had no statistical significance (p > 0.05); the content of D-dimer of AECOPD patients was in a negative correlation with FEV1 and PO (p smaller than 0.05) and in a positive correlation with PCO (p smaller than 0.05). It can be concluded that D-dimer is correlated to the severity of AECOPD; hence, it can be used as an evaluation index for the severity of AECOPD.
本研究旨在观察慢性阻塞性肺疾病急性加重期（AECOPD）患者血浆D-二聚体的变化。将患者分为三组，即AECOPD组、稳定期慢性阻塞性肺疾病组（治疗后病情保持稳定的慢性阻塞性肺疾病组）和健康对照组。检测所有研究对象的血浆纤维蛋白原（FIB）和D-二聚体含量，并分析组间差异。此外，检测AECOPD组和稳定期慢性阻塞性肺疾病组患者的肺功能，包括第1秒用力呼气量（FEV1%）和第1秒用力肺活量率（FEV1/FVC）以及血气（氧分压（PO）和二氧化碳分压（PaCO₂））；分析两组之间的差异及可能的相关性。与慢性阻塞性肺疾病稳定组和对照组相比，AECOPD组血浆FIB和D-二聚体含量在统计学上显著更高（p＜0.05）；慢性阻塞性肺疾病稳定组血浆FIB和D-二聚体含量远高于健康对照组，但差异无统计学意义（p＞0.05）；AECOPD患者的D-二聚体含量与FEV1和PO呈负相关（p＜0.05），与PCO₂呈正相关（p＜0.05）。可以得出结论，D-二聚体与AECOPD的严重程度相关；因此，它可作为AECOPD严重程度的评估指标。
