Matwijiw I, Thliveris J A, Faiman C
Department of Medicine, University of Manitoba, Winnipeg, Canada.
Biol Reprod. 1989 May;40(5):1127-30. doi: 10.1095/biolreprod40.5.1127.
The ontogeny of the hypothalamo-pituitary portal system was studied in six ovine fetuses, 48-67 days of gestation (term = 147 days) after infusion of the vascular system with a silicone rubber compound. In all of these fetuses, a marked orange blush of silicone rubber could be seen, under the dissecting microscope, extending down the stalk from the hypothalamus to the pituitary. On microscopic examination, extensive and well-developed capillary connections between the median eminence, the pituitary stalk, and pituitary gland were seen in all fetuses. In an additional fetus, aged 45 days, which was not perfused with silicone rubber, portal capillary loops had penetrated the median eminence. These findings suggest that, in the ovine fetus, hypothalamic releasing factors can be transported directly via a portal vascular route to the pituitary gland as early as 45 days of gestation.
在向6只妊娠48 - 67天（足月为147天）的绵羊胎儿的血管系统注入硅橡胶化合物后，对下丘脑 - 垂体门脉系统的个体发生进行了研究。在所有这些胎儿中，在解剖显微镜下可以看到明显的硅橡胶橙色红晕，从下丘脑沿着柄向下延伸至垂体。显微镜检查发现，所有胎儿的正中隆起、垂体柄和垂体之间都有广泛且发育良好的毛细血管连接。在另一只未注入硅橡胶的45天龄胎儿中，门脉毛细血管襻已经穿透了正中隆起。这些发现表明，在绵羊胎儿中，早在妊娠45天时，下丘脑释放因子就可以通过门脉血管途径直接运输到垂体。
