两只犬颅内出血应用重组人粒细胞集落刺激因子（rhG-CSF）的病例报告
Administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) for the intracranial hemorrhage in two dogs: a case report.
作者信息
Kang M H, Park H M
机构信息
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, South Korea.
出版信息
Iran J Vet Res. 2016 Winter;17(1):62-5.
Two dogs with generalized seizures were evaluated. The dogs were diagnosed with traumatic intracranial hemorrhages based on the history, neurological examinations, and magnetic resonance imaging (MRI) of the brain. Treatment was started with oxygen, prednisolone and anticonvulsant agents. No further seizure activity was observed after treatment in both dogs, however cushing reflex was detected in case 1 and a left-sided hemi-paresis was detected in case 2. Further supportive treatment with recombinant human granulocyte colony-stimulating factor (rhG-CSF) was attempted. No abnormal signs were noted in either of the dogs and no recurrence was noted 16 and 14 months later, in case 1 and 2, respectively. These cases indicate that a combination of rhG-CSF treatment with previous therapy could be used in dogs with traumatic brain injury.
对两只患有全身性癫痫发作的犬进行了评估。根据病史、神经学检查和脑部磁共振成像（MRI），这两只犬被诊断为创伤性颅内出血。治疗从给予氧气、泼尼松龙和抗惊厥药物开始。两只犬在治疗后均未观察到进一步的癫痫发作活动，然而在病例1中检测到了库欣反射，在病例2中检测到了左侧偏瘫。尝试用重组人粒细胞集落刺激因子（rhG-CSF）进行进一步的支持治疗。两只犬均未出现异常体征，并且在病例1和病例2中，分别在16个月和14个月后未观察到复发。这些病例表明，rhG-CSF治疗与先前治疗相结合可用于患有创伤性脑损伤的犬。
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