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Selective serotonin reuptake inhibitors and pregnancy: A review of maternal, fetal and neonatal risks and benefits.选择性5-羟色胺再摄取抑制剂与妊娠：对母体、胎儿及新生儿风险与益处的综述
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2
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3
Selective serotonin reuptake inhibitor use during pregnancy and possible neonatal complications.孕期使用选择性5-羟色胺再摄取抑制剂及可能的新生儿并发症。
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BJOG. 2016 Nov;123(12):1900-1907. doi: 10.1111/1471-0528.14144. Epub 2016 May 30.
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Medications with Potential for Fetal Risk Prescribed to Veterans.给退伍军人开具有潜在胎儿风险的药物。
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Selective serotonin reuptake inhibitors in pregnancy.选择性 5-羟色胺再摄取抑制剂在妊娠中的应用。
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What are the risks associated with different Selective Serotonin Re-uptake Inhibitors (SSRIs) to treat depression and anxiety in pregnancy? An evaluation of current evidence.不同的选择性5-羟色胺再摄取抑制剂（SSRI）用于治疗孕期抑郁和焦虑的相关风险有哪些？当前证据评估。
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Selective serotonin re-uptake inhibitors affect craniofacial structures in a mouse model.选择性 5-羟色胺再摄取抑制剂影响小鼠模型中的颅面结构。
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SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology.SSRIs 治疗可改变母体炎症对宫内生理和后代神经生物学的影响。
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Therapeutic termination of pregnancy and women's mental health: Determinants and consequences.治疗性终止妊娠与女性心理健康：决定因素及后果
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Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives.所选抗抑郁药对血清素胎盘稳态的影响：母体和胎儿视角
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本文引用的文献

1
SSRI use during pregnancy and risk of stillbirth and neonatal mortality.妊娠期使用 SSRIs 与死产和新生儿死亡风险。
Am J Psychiatry. 2013 Mar;170(3):299-304. doi: 10.1176/appi.ajp.2012.11081251.
2
Infant and childhood neurodevelopmental outcomes following prenatal exposure to selective serotonin reuptake inhibitors: overview and design of a Finnish Register-Based Study (FinESSI).选择性 5-羟色胺再摄取抑制剂产前暴露对婴幼儿神经发育的影响：芬兰基于登记的研究（FinESSI）概述和设计。
BMC Psychiatry. 2012 Dec 4;12:217. doi: 10.1186/1471-244X-12-217.
3
Newer generation antidepressants for depressive disorders in children and adolescents.用于儿童和青少年抑郁症的新一代抗抑郁药。
Cochrane Database Syst Rev. 2012 Nov 14;11(11):CD004851. doi: 10.1002/14651858.CD004851.pub3.
4
Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression.母亲孕期暴露于文拉法辛、选择性 5-羟色胺再摄取抑制剂或未治疗的抑郁症后儿童的神经发育。
Am J Psychiatry. 2012 Nov;169(11):1165-74. doi: 10.1176/appi.ajp.2012.11111721.
5
Selective serotonin reuptake inhibitors in pregnancy and infant outcomes.孕期使用选择性5-羟色胺再摄取抑制剂与婴儿结局
Paediatr Child Health. 2011 Nov;16(9):562-3. doi: 10.1093/pch/16.9.562.
6
Maternal use of SSRIs, SNRIs and NaSSAs: practical recommendations during pregnancy and lactation.母亲使用 SSRIs、SNRIs 和 NaSSAs：妊娠期和哺乳期的实用建议。
Arch Dis Child Fetal Neonatal Ed. 2012 Nov;97(6):F472-6. doi: 10.1136/archdischild-2011-214239.
7
Do findings differ across research design? The case of antidepressant use in pregnancy and malformations.不同研究设计的结果是否存在差异？孕期使用抗抑郁药与畸形的案例。
J Popul Ther Clin Pharmacol. 2012;19(2):e334-48. Epub 2012 Aug 29.
8
Neonatal outcomes after late-gestation exposure to selective serotonin reuptake inhibitors.孕晚期暴露于选择性 5-羟色胺再摄取抑制剂后的新生儿结局。
J Clin Psychopharmacol. 2012 Oct;32(5):615-21. doi: 10.1097/JCP.0b013e31826686bc.
9
Early morbidity and mortality following in utero exposure to selective serotonin reuptake inhibitors: a population-based study in Western Australia.子宫内暴露于选择性 5-羟色胺再摄取抑制剂后的早期发病率和死亡率：西澳大利亚的一项基于人群的研究。
CNS Drugs. 2012 Jul 1;26(7):e1-14. doi: 10.2165/11634190-000000000-00000.
10
Exposure to selective serotonin reuptake inhibitors and the risk of congenital malformations: a nationwide cohort study.选择性5-羟色胺再摄取抑制剂的暴露与先天性畸形风险：一项全国性队列研究。
BMJ Open. 2012 Jun 18;2(3). doi: 10.1136/bmjopen-2012-001148. Print 2012.

选择性5-羟色胺再摄取抑制剂与妊娠：对母体、胎儿及新生儿风险与益处的综述

Selective serotonin reuptake inhibitors and pregnancy: A review of maternal, fetal and neonatal risks and benefits.

作者信息

Marchocki Zbigniew, Russell Noirin E, Donoghue Keelin O'

机构信息

Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.

出版信息

Obstet Med. 2013 Dec;6(4):155-8. doi: 10.1177/1753495X13495194. Epub 2013 Aug 8.

DOI:10.1177/1753495X13495194
PMID:27656248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5004326/
Abstract

Depression is common in women of childbearing age. Whereas non-pharmacological interventions are recommended as first line interventions, pharmacological treatment may be required. Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants in pregnancy. Ideally, discussion of the risks and benefits of SSRI use in pregnancy should occur prior to pregnancy. The potential risks of psychotropic medications need to be balanced against the risks associated with untreated psychiatric conditions and the discontinuation of necessary medications.

摘要

抑郁症在育龄女性中很常见。虽然推荐非药物干预作为一线干预措施，但可能需要药物治疗。选择性5-羟色胺再摄取抑制剂（SSRI）是孕期最常用的抗抑郁药。理想情况下，应在怀孕前讨论孕期使用SSRI的风险和益处。精神药物的潜在风险需要与未治疗的精神疾病以及停用必要药物相关的风险相权衡。