合并子痫前期及非子痫前期相关肾病范围蛋白尿的妊娠
Pregnancies complicated by preeclampsia and non-preeclampsia-related nephrotic range proteinuria.
作者信息
Brown R A, Kemp G J, Walkinshaw S A, Howse Mlp
机构信息
Royal Liverpool and Broadgreen University Hospitals NHS Trust, UK.
Institute of Ageing and Chronic Disease, University of Liverpool, UK.
出版信息
Obstet Med. 2013 Dec;6(4):159-64. doi: 10.1177/1753495X13498382. Epub 2013 Aug 13.
OBJECTIVE
To examine the impact of nephrotic range proteinuria during pregnancy on renal, maternal and fetal outcomes.
METHODS
A retrospective study of pregnant women with proteinuria greater than 3 g/24 h. Outcome measures included: gestation and mode of delivery, maternal high dependency unit admission, birth weight, maternal blood pressure and proteinuria at time of last follow-up, renal biopsy.
RESULTS
Two hundred and sixty four pregnancies in 262 women were reviewed. Postnatal data were available in 180; of these 104 (57%) had urinary protein quantified postnatally. Sixty three (60%) were pure preeclampsia and nine (9%) super-imposed preeclampsia. Biopsy-proven renal disease was newly diagnosed in nine (9%). Sixty three per cent required caesarean section and 34% required high dependency unit admission. There were no maternal deaths. Birth weight corrected for gestation was below the fifth centile in 33%.
CONCLUSIONS
The incidence of underlying renal pathology in this cohort is significant and highlights the importance of careful follow-up.
目的
探讨孕期肾病范围蛋白尿对肾脏、母体及胎儿结局的影响。
方法
对蛋白尿大于3 g/24 h的孕妇进行回顾性研究。结局指标包括：孕周及分娩方式、产妇入住高依赖病房情况、出生体重、末次随访时的产妇血压及蛋白尿情况、肾活检。
结果
对262名女性的264次妊娠进行了回顾。180例有产后数据；其中104例（57%）产后进行了尿蛋白定量。63例（60%）为单纯子痫前期，9例（9%）为叠加子痫前期。9例（9%）经活检证实为新诊断的肾脏疾病。63%需要剖宫产，34%需要入住高依赖病房。无孕产妇死亡。校正孕周后的出生体重低于第5百分位数的占33%。
结论
该队列中潜在肾脏病理的发生率较高，凸显了密切随访的重要性。
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