Edwards J A, Bernhardt B, Schnatz J D
J Med. 1978;9(2):157-82.
Fasting serum cholesterol and triglyceride levels were measured in 131 randomly selected adult members of a Lebanese Community of Western New York. Mean cholesterol levels (males, 217 mg%; females 234 mg%) were higher than those reported from the Lebanon but similar to those reported in most other populations. Mean triglyceride levels (males, 153 mg%; females, 115 mg%) were higher than those reported in most other populations. Twenty-three subjects were hyperlipidemic on the basis of age and frequency distribution adjusted serum lipid levels above the 90th percentile. Clinical and family studies carried out on 13 of these 23 hyperlipidemic subjects suggested that 77% had monogenic hyperlipidemia and 23% primary non-monogenic hyperlipidemia. A high frequency of familial hypercholesterolemia (minimum estimate 0.7%) was found, in keeping with the high frequency of the disorder in Lebanon. The study serves to emphasize the difficulties in defining hyperlipidemia, in establishing a specific diagnosis in the individual patient, and in distinguishing between optimum and normal serum lipid levels.
对纽约西部黎巴嫩社区随机选取的131名成年成员测定了空腹血清胆固醇和甘油三酯水平。平均胆固醇水平（男性为217mg%；女性为234mg%）高于黎巴嫩报告的水平，但与大多数其他人群报告的水平相似。平均甘油三酯水平（男性为153mg%；女性为115mg%）高于大多数其他人群报告的水平。根据年龄和频率分布调整后，有23名受试者血清脂质水平高于第90百分位数，属于高脂血症患者。对这23名高脂血症患者中的13名进行的临床和家族研究表明，77%患有单基因高脂血症，23%患有原发性非单基因高脂血症。发现家族性高胆固醇血症的发生率较高（最低估计为0.7%），这与黎巴嫩该病的高发生率相符。该研究强调了在定义高脂血症、对个体患者进行明确诊断以及区分最佳和正常血清脂质水平方面存在的困难。
