骨量峰值较低的SAM-P/6小鼠在皮质骨塑形过程中骨内膜形成减少。

Decreased endosteal formation during cortical bone modelling in SAM-P/6 mice with a low peak bone mass.

作者信息

Tsuboyama T, Takahashi K, Matsushita M, Okumura H, Yamamuro T, Umezawa M, Takeda T

机构信息

Department of Orthopedic Surgery, Faculty of Medicine, Kyoto University, Japan.

出版信息

Bone Miner. 1989 Aug;7(1):1-12. doi: 10.1016/0169-6009(89)90058-5.

DOI:10.1016/0169-6009(89)90058-5

PMID:2765711

Abstract

Inter-strain differences in bone mass and density during growth were followed in three strains of mice: SAM-P/2, SAM-R/1 and SAM-P/6 (a murine model of senile osteoporosis, Matsushita et al., Am J Pathol 1986;125:276-283). Photometrically, the inter-strain disparities first appeared in mice at about age 28 days and increased until age 60 days. During this period, tetracycline labelling revealed significant strain differences regarding rate of the appositional formation at the endosteal surface but not at the periosteal surface. The order coincided with results of the photometrical assay, that is, highest in SAM-P/2, followed by SAM-R/1 and SAM-P/6, respectively. Therefore, strain differences, especially the osteopenic state of SAM-P/6, occur, at least in part, by disparities in endosteal formation rates during cortical bone modelling.

摘要

对三种品系的小鼠（SAM-P/2、SAM-R/1和SAM-P/6，一种老年性骨质疏松症的小鼠模型，松下等人，《美国病理学杂志》1986年；125:276 - 283）生长期间的骨量和骨密度的品系间差异进行了跟踪研究。通过光度测定法，品系间差异首先在约28日龄的小鼠中出现，并一直增加到60日龄。在此期间，四环素标记显示，在内膜表面的贴壁形成速率方面存在显著的品系差异，但在骨膜表面则没有。这种顺序与光度测定结果一致，即SAM-P/2最高，其次分别是SAM-R/1和SAM-P/6。因此，品系差异，尤其是SAM-P/6的骨质减少状态，至少部分是由于皮质骨建模期间内膜形成速率的差异所致。