对离子型谷氨酸受体变构调节的深入洞察。
Deeper Insights into the Allosteric Modulation of Ionotropic Glutamate Receptors.
作者信息
Regan Michael C, Furukawa Hiro
机构信息
W.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.
W.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.
出版信息
Neuron. 2016 Sep 21;91(6):1187-1189. doi: 10.1016/j.neuron.2016.09.013.
Abstract
Two articles in this issue of Neuron (Yelshanskaya et al., 2016; Yi et al., 2016) explore the structural basis of allosteric inhibition in ionotropic glutamate receptors, providing key insights into how iGluRs function in the brain as well as how they might be pharmacologically modulated in neurological disorders and disease.
摘要
本期《神经元》杂志上的两篇文章（叶尔尚斯卡娅等人，2016年；易等人，2016年）探讨了离子型谷氨酸受体变构抑制的结构基础，为离子型谷氨酸受体在大脑中的功能以及在神经系统疾病中如何进行药理调节提供了关键见解。
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2
Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.含GluN2A的N-甲基-D-天冬氨酸受体负变构调节的结构基础
Neuron. 2016 Sep 21;91(6):1316-1329. doi: 10.1016/j.neuron.2016.08.014. Epub 2016 Sep 8.
3
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.具有不同作用模式和对回路功能影响的 GluN2A 包含型 NMDA 受体的正变构调节剂。
Neuron. 2016 Mar 2;89(5):983-99. doi: 10.1016/j.neuron.2016.01.016. Epub 2016 Feb 11.
4
A structural biology perspective on NMDA receptor pharmacology and function.从结构生物学角度看NMDA受体药理学与功能
Curr Opin Struct Biol. 2015 Aug;33:68-75. doi: 10.1016/j.sbi.2015.07.012. Epub 2015 Aug 15.
5
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6
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7
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