Bondoux-Jahan M, Sebille A
Laboratoire de Physiologie, Faculté de Médecine Saint Antoine, Paris, France.
Brain Res. 1989 Jun 26;490(2):350-4. doi: 10.1016/0006-8993(89)90253-9.
The rate of regeneration and the initial delay of the fastest growing fibers of the rat sciatic nerve were electrophysiologically evaluated after a freeze at mid-thigh. A prior section or a prior freeze at the ankle level increased the rate of regeneration and decreased the initial delay with different magnitudes. These phenomena are named 'conditioning lesion effects'. A daily electrical stimulation transcutaneously delivered to the foot sole muscles from the day following their denervation by the prior lesion did not modify the increased rate of regeneration but prevented the decrease of the initial delay whatever the type of the prior lesion. Therefore, the initiation of earlier sprouting of the parent axons seems to be specifically controlled by a signal associated with muscle denervation properties.
在大鼠坐骨神经大腿中部冷冻后，通过电生理方法评估了再生速率以及生长最快的纤维的初始延迟。先前在踝关节水平进行的切断或冷冻会以不同程度提高再生速率并缩短初始延迟。这些现象被称为“预处理损伤效应”。在先前损伤导致足底肌肉失神经支配后的第二天开始，每天经皮对足底肌肉进行电刺激，无论先前损伤的类型如何，均不会改变提高的再生速率，但可防止初始延迟的缩短。因此，母轴突更早发芽的起始似乎由与肌肉失神经支配特性相关的信号特异性控制。
