Cancer Discov. 2016 Nov;6(11):1203. doi: 10.1158/2159-8290.CD-NB2016-118. Epub 2016 Sep 22.
DNA methylation profiling may have potential in unmasking the origin of tumors classified as cancer of unknown primary. A diagnostic assay developed by the researchers, EPICUP, predicted the primary tumor site in 87% of 216 cases, and these predictions were subsequently verified through various tests, including immunohistochemistry.
DNA 甲基化分析可能有助于揭示被归类为不明原发灶癌的肿瘤的起源。研究人员开发的诊断检测方法 EPICUP 预测了 216 例病例中的 87%的原发肿瘤部位，这些预测随后通过包括免疫组织化学在内的各种测试得到了验证。
