McGregor I S, Balleine B W, Atrens D M
Department of Psychology, University of Sydney, N.S.W., Australia.
Brain Res. 1989 Jun 26;490(2):397-403. doi: 10.1016/0006-8993(89)90261-8.
The effects of stress on self-stimulation were investigated by exposing rats to either controllable, uncontrollable or no footshock. Both controllable and uncontrollable footshock increased medial prefrontal cortex self-stimulation rates immediately as well as 24 h following treatment. Controllable footshock produced a greater enhancement than uncontrollable footshock. In contrast, self-stimulation of the lateral hypothalamus was unaffected by either footshock treatment. These results are interpreted with reference to the neurochemical response of the mesocortical dopaminergic system to acute stress.
通过让大鼠遭受可控、不可控或无电击，研究了应激对自我刺激的影响。可控和不可控电击都会立即以及在处理后24小时增加内侧前额叶皮质的自我刺激率。可控电击比不可控电击产生的增强作用更大。相比之下，外侧下丘脑的自我刺激不受任何一种电击处理的影响。这些结果参照中脑皮质多巴胺能系统对急性应激的神经化学反应进行了解释。
