Koh Jieun, Kim Eun-Kyung, Kim Ji-Ye, Kwak Jin Young, Yoon Jung Hyun, Moon Hee Jung
Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Ultrasound Med Biol. 2016 Dec;42(12):2864-2872. doi: 10.1016/j.ultrasmedbio.2016.08.009. Epub 2016 Sep 19.
The aim of the study described here was to compare ultrasound features, pathologic characteristics and prognoses of the follicular variant of papillary thyroid carcinoma (FVPTC) according to cytology results. Eighty-seven FVPTCs were classified according to the first cytology results as the surgery group (n = 66, follicular neoplasm/Hürthle cell neoplasm, suspicious for malignancy and malignancy) and the indeterminate group (n = 21, non-diagnostic and benign), for whom the management was follow-up. The indeterminate group had a longer mean interval to surgery (p = 0.020) and larger tumor size (p = 0.018). More tumors were assessed as probably benign in the indeterminate group than in the surgery group (p < 0.001). Extrathyroidal extension and lymph node metastasis did not significantly differ between the two groups, and no patient had a recurrence (mean follow-up interval: 54.9 ± 16.9 mo). The indeterminate group exhibited more probably benign features and larger size on ultrasound, with surgery being performed at a later date. However, aggressive pathologic characteristics and tumor recurrence did not significantly differ between the two groups.
本研究的目的是根据细胞学结果比较甲状腺乳头状癌滤泡变体（FVPTC）的超声特征、病理特征和预后。87例FVPTC根据首次细胞学结果分为手术组（n = 66，滤泡性肿瘤/许特莱细胞肿瘤，可疑恶性和恶性）和不确定组（n = 21，非诊断性和良性），对不确定组进行随访观察。不确定组的平均手术间隔时间更长（p = 0.020），肿瘤尺寸更大（p = 0.018）。不确定组中评估为可能良性的肿瘤比手术组更多（p < 0.001）。两组之间甲状腺外侵犯和淋巴结转移无显著差异，且无患者复发（平均随访间隔：54.9 ± 16.9个月）。不确定组在超声检查中表现出更多可能为良性的特征且尺寸更大，手术时间较晚。然而，两组之间侵袭性病理特征和肿瘤复发无显著差异。
