Figlewicz D P, Sipols A J, Green P, Porte D, Woods S C
Department of Psychology, University of Washington, Seattle 98195.
Brain Res Bull. 1989 May;22(5):849-52. doi: 10.1016/0361-9230(89)90029-4.
In this study, we compared the effectiveness of intravenous (IV) vs. intraventricular (IVT) cholecystokinin octapeptide (CCK-8) to decrease single meal size over a dose range of 0.1 to 4.0 micrograms/kg in a population of overnight fasted baboons. IV CCK did not decrease meal size significantly at doses of 0.5, 1, and 4 micrograms/kg (84 +/- 22%, 78 +/- 12%, and 89 +/- 33% of paired control meal sizes respectively). IVT CCK significantly decreased single meal size at all doses tested (40 +/- 18%, 26 +/- 10%, 37 +/- 15%, 26 +/- 12%, and 12 +/- 6% of paired control meal sizes at 0.1, 0.25, 0.5, 1, and 2 micrograms/kg respectively). Meal suppression with IVT CCK was significantly greater than that achieved with IV CCK at doses of 1 and 2 micrograms/kg. We conclude that in the baboon, CCK may have a direct effect at the central nervous system to suppress single meal size.
在本研究中，我们比较了静脉注射（IV）与脑室内注射（IVT）胆囊收缩素八肽（CCK-8）在禁食过夜的狒狒群体中，在0.1至4.0微克/千克剂量范围内减少单次进餐量的效果。静脉注射CCK在0.5、1和4微克/千克剂量时，并未显著降低进餐量（分别为配对对照进餐量的84±22%、78±12%和89±33%）。脑室内注射CCK在所有测试剂量下均显著降低单次进餐量（在0.1、0.25、0.5、1和2微克/千克时，分别为配对对照进餐量的40±18%、26±10%、37±15%、26±12%和12±6%）。在1和2微克/千克剂量时，脑室内注射CCK对进餐的抑制作用显著大于静脉注射CCK。我们得出结论，在狒狒中，CCK可能在中枢神经系统具有直接作用以抑制单次进餐量。
