针对患有半球型低级别胶质瘤儿童的正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）研究。
PET and SPECT studies in children with hemispheric low-grade gliomas.
作者信息
Juhász Csaba, Bosnyák Edit
机构信息
Departments of Pediatrics, Wayne State University, Detroit, MI, USA.
Departments of Neurology, Wayne State University, Detroit, MI, USA.
出版信息
Childs Nerv Syst. 2016 Oct;32(10):1823-32. doi: 10.1007/s00381-016-3125-z. Epub 2016 Sep 20.
Molecular imaging is playing an increasing role in the pretreatment evaluation of low-grade gliomas. While glucose positron emission tomography (PET) can be helpful to differentiate low-grade from high-grade tumors, PET imaging with amino acid radiotracers has several advantages, such as better differentiation between tumors and non-tumorous lesions, optimized biopsy targeting, and improved detection of tumor recurrence. This review provides a brief overview of single-photon emission computed tomography (SPECT) studies followed by a more detailed review of the clinical applications of glucose and amino acid PET imaging in low-grade hemispheric gliomas. We discuss key differences in the performance of the most commonly utilized PET radiotracers and highlight the advantage of PET/MRI fusion to obtain optimal information about tumor extent, heterogeneity, and metabolism. Recent data also suggest that simultaneous acquisition of PET/MR images and the combination of advanced MRI techniques with quantitative PET can further improve the pretreatment and post-treatment evaluation of pediatric brain tumors.
分子成像在低级别胶质瘤的治疗前评估中发挥着越来越重要的作用。虽然葡萄糖正电子发射断层扫描（PET）有助于区分低级别和高级别肿瘤，但使用氨基酸放射性示踪剂的PET成像具有多个优势，例如肿瘤与非肿瘤性病变之间的区分更好、活检靶向优化以及肿瘤复发检测的改善。本综述简要概述了单光子发射计算机断层扫描（SPECT）研究，随后更详细地回顾了葡萄糖和氨基酸PET成像在低级别半球胶质瘤中的临床应用。我们讨论了最常用的PET放射性示踪剂在性能上的关键差异，并强调了PET/MRI融合在获取有关肿瘤范围、异质性和代谢的最佳信息方面的优势。最新数据还表明，同时采集PET/MR图像以及将先进的MRI技术与定量PET相结合可以进一步改善儿童脑肿瘤的治疗前和治疗后评估。
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