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腹膜透析患者的无症状流出液原生动物定植

Asymptomatic Effluent Protozoa Colonization in Peritoneal Dialysis Patients.

作者信息

Simões-Silva Liliana, Correia Inês, Barbosa Joana, Santos-Araujo Carla, Sousa Maria João, Pestana Manuel, Soares-Silva Isabel, Sampaio-Maia Benedita

机构信息

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal Serviço de Microbiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.

Faculdade de Medicina Dentária, Universidade do Porto, Porto, Portugal.

出版信息

Perit Dial Int. 2016;36(5):566-9. doi: 10.3747/pdi.2015.00226.

Abstract

Currently, chronic kidney disease (CKD) is a global health problem. Considering the impaired immunity of CKD patients, the relevance of infection in peritoneal dialysis (PD), and the increased prevalence of parasites in CKD patients, protozoa colonization was evaluated in PD effluent from CKD patients undergoing PD. Overnight PD effluent was obtained from 49 asymptomatic stable PD patients. Protozoa analysis was performed microscopically by searching cysts and trophozoites in direct wet mount of PD effluent and after staining smears. Protozoa were found in PD effluent of 10.2% of evaluated PD patients, namely Blastocystis hominis, in 2 patients, and Entamoeba sp., Giardia sp., and Endolimax nana in the other 3 patients, respectively. None of these patients presented clinical signs or symptoms of peritonitis at the time of protozoa screening. Our results demonstrate that PD effluent may be susceptible to asymptomatic protozoa colonization. The clinical impact of this finding should be further investigated.

摘要

目前,慢性肾脏病(CKD)是一个全球性的健康问题。考虑到CKD患者免疫力受损、腹膜透析(PD)中感染的相关性以及CKD患者寄生虫患病率增加,对接受PD治疗的CKD患者的PD流出液中的原生动物定植情况进行了评估。从49例无症状稳定PD患者中获取过夜PD流出液。通过在PD流出液的直接湿片中以及涂片染色后寻找囊肿和滋养体,进行原生动物显微镜分析。在10.2%的评估PD患者的PD流出液中发现了原生动物,即2例患者中有蓝氏贾第鞭毛虫,另外3例患者分别有内阿米巴属、贾第虫属和微小内蜒阿米巴。在原生动物筛查时,这些患者均未出现腹膜炎的临床体征或症状。我们的数据表明,PD流出液可能易受无症状原生动物定植的影响。这一发现的临床影响应进一步研究。

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