Hua Ying, Zhang Wenwen, Hu Xiaoli, Yang Ansu, Zhu Xueqiong
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Drug Des Devel Ther. 2016 Sep 6;10:2789-2801. doi: 10.2147/DDDT.S111625. eCollection 2016.
The effects of misoprostol use on cervical priming prior to hysteroscopy have been controversial. Therefore, a systematic literature review and meta-analysis of studies were conducted to assess the effect of misoprostol on cervical priming prior to hysteroscopy. All studies published before July 2014 with data related to the use of misoprostol for cervical priming compared with placebo or no medication prior to hysteroscopy, were identified. Twenty-five randomized controlled trials involving 2,203 females were systematically analyzed. The results showed that, compared with placebo or no medication, the use of misoprostol prior to hysteroscopy led to a significant relief of the need for cervical dilatation, resulted in a significantly greater cervical width, had fewer hysteroscopy complications, and mild and insignificant side effects. Subgroup analyses revealed that the regimen of 200 or 400 μg vaginal misoprostol may be a simple and effective method for cervical priming, especially prior to operative hysteroscopy.
米索前列醇在宫腔镜检查前用于宫颈准备的效果一直存在争议。因此，我们进行了一项系统的文献综述和研究的荟萃分析，以评估米索前列醇在宫腔镜检查前对宫颈准备的影响。我们检索了2014年7月之前发表的所有与米索前列醇用于宫颈准备相关的数据的研究，并将其与宫腔镜检查前使用安慰剂或不使用药物的情况进行比较。我们系统分析了25项涉及2203名女性的随机对照试验。结果表明，与安慰剂或不使用药物相比，宫腔镜检查前使用米索前列醇可显著减轻宫颈扩张的需求，使宫颈宽度显著增加，宫腔镜检查并发症更少，且副作用轻微且不显著。亚组分析显示，200或400μg阴道米索前列醇方案可能是一种简单有效的宫颈准备方法，尤其是在手术宫腔镜检查前。
