Taguchi M, Uehara M, Asashima M, Pfeiffer C J
Department of Biology, Yokohama City University, Japan.
Cell Differ Dev. 1989 Jul;27(2):95-102. doi: 10.1016/0922-3371(89)90739-9.
Development of cardiac contraction was investigated in the newt, Cynops pyrrhogaster, during normal development and in hearts maintained in long-term organ culture. In the embryos the heart began beating as early as stage 33. The heart rate increased up to stage 52 and then gradually decreased to the adult rate by stage 60. The heart rate showed a logarithmic temperature dependence. In organ-cultured hearts the pattern of heart rate depended on the stage at which the heart was explanted; cultured embryonic hearts showed a pattern of increase and decline similar to that seen in vivo, and hearts explanted near metamorphosis showed only a slow decline.
在正常发育过程中以及长期器官培养的心脏中，对东方蝾螈的心脏收缩发育进行了研究。在胚胎中，心脏早在第33阶段就开始跳动。心率在第52阶段之前增加，然后在第60阶段逐渐降至成年心率。心率呈现对数温度依赖性。在器官培养的心脏中，心率模式取决于心脏被移出的阶段；培养的胚胎心脏呈现出与体内观察到的类似的增减模式，而在变态期附近移出的心脏仅显示出缓慢下降。
