Ozsutcu Mustafa, Balci Ozlem, Tanriverdi Cafer, Demirci Goktug
Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Bagcilar, 34214, Istanbul, Turkey.
Eur Arch Otorhinolaryngol. 2017 Feb;274(2):873-877. doi: 10.1007/s00405-016-4308-7. Epub 2016 Sep 23.
The objective of the study was to compare the success rate of transcanalicular laser dacryocystorhinostomy (TCL-DCR) with or without the use of adjunctive mitomycin C (MMC) in cases with primary nasolacrimal duct obstruction (NLDO). This retrospective study was comprised of 68 patients with uncomplicated primary NLDO. There were two groups in the study: the Group 1 (n = 35) patients underwent TCL-DCR surgery with MMC and the Group 2 (n = 33) patients underwent TCL-DCR surgery without MMC. All patients had bicanalicular silicone tube intubation. The main outcome measures were patent osteotomy as visualized endoscopically and patent nasolacrimal irrigation. The follow-up period was 12 months. All patients had unilateral TCL-DCR with silicone tube intubation. Six months following surgery, the silicone tubes were removed. At the final evaluation, success rates were 80 % in Group 1 and 78.8 % in Group 2. There was no statistically significant difference between the two groups (p = 0.52). No complications related to MMC usage were recorded during the study period. Intraoperative use of MMC has no beneficial effect on the success rate in TCL-DCR.
本研究的目的是比较在原发性鼻泪管阻塞（NLDO）病例中，使用或不使用辅助性丝裂霉素C（MMC）的经泪小管激光泪囊鼻腔造口术（TCL-DCR）的成功率。这项回顾性研究纳入了68例单纯性原发性NLDO患者。研究分为两组：第1组（n = 35）患者接受了联合MMC的TCL-DCR手术，第2组（n = 33）患者接受了未使用MMC的TCL-DCR手术。所有患者均进行了双泪小管硅胶管插管。主要观察指标为内镜下可见的切开通畅和鼻泪管冲洗通畅。随访期为12个月。所有患者均接受了单侧带硅胶管插管的TCL-DCR手术。术后6个月，取出硅胶管。在最终评估时，第1组的成功率为80%，第2组为78.8%。两组之间无统计学显著差异（p = 0.52）。在研究期间，未记录到与使用MMC相关的并发症。术中使用MMC对TCL-DCR的成功率没有有益影响。
