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翼状胬肉治疗的进展与当前方法

Developments and current approaches in the treatment of pterygium.

作者信息

Hacıoğlu Dilek, Erdöl Hidayet

机构信息

The State Hospital of Iğdır, Kışla Neighborhood, Melekli Mainstreet, Iğdır, Turkey.

Department of Ophthalmology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.

出版信息

Int Ophthalmol. 2017 Aug;37(4):1073-1081. doi: 10.1007/s10792-016-0358-5. Epub 2016 Sep 23.

Abstract

PURPOSE

To assess and compare the studies conducted in the literature with recurrence rates and the summary of the justified treatment approaches be presented.

METHOD

Pterygium, a fibrovascular tissue that proceeds from the bulbar conjunctiva towards the cornea, is quite a commonly seen ocular surface deterioration. The treatment is performed through a surgical excision, and the frequent recurrence of this disorder, despite the developments of today, is the major problem experienced in the wake of the surgery. There are various treatment methods applied for the prevention of recurrence; yet, there is no definite view as to what treatment is the most effective one. Since the recurrent pterygium cases are more aggressive than the primary pterygium, it is of great importance to determine the treatment method in which recurrence rate is the lowest. In different studies seen in the literature, there is difficulty in comparing the results due to the fact that the follow-up periods, recurrence criteria and the doses and durations of the medications administered differ from one another.

CONCLUSION

When the literature is reviewed, the bare sclera technique is not used due to the high rate of recurrence, whereas successful results can be achieved through the conjunctival autograft technique. Lower recurrence rates have been reported along with the administration of mitomycin C, 5-FU and other agents that were used as an adjuvant treatment.

摘要

目的

评估和比较文献中关于复发率的研究,并呈现合理治疗方法的总结。

方法

翼状胬肉是一种从球结膜向角膜生长的纤维血管组织,是一种常见的眼表病变。治疗通过手术切除进行,尽管当今有了各种进展,但这种疾病术后频繁复发仍是主要问题。有多种预防复发的治疗方法;然而,对于哪种治疗最有效尚无定论。由于复发性翼状胬肉病例比原发性翼状胬肉更具侵袭性,确定复发率最低的治疗方法非常重要。在文献中不同的研究里,由于随访期、复发标准以及所使用药物的剂量和疗程各不相同,难以比较结果。

结论

回顾文献时,由于复发率高,未采用单纯巩膜技术,而结膜自体移植技术可取得成功结果。据报道,使用丝裂霉素C、5-氟尿嘧啶和其他用作辅助治疗的药物可降低复发率。

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