Kiyoshima K, Sakamoto M, Ishikura T, Fukagawa Y, Yoshioka T, Naganawa H, Sawa T, Takeuchi T
Chem Pharm Bull (Tokyo). 1989 Apr;37(4):861-5. doi: 10.1248/cpb.37.861.
4''-O-Acyl-, 4''-O-alkyl- and 4''-deoxy-tylosin derivatives were synthesized using 2'-O-acetyl-3'',4''-O-(dibutyl-stannio)tylosin as a synthetic intermediate. The in vitro biological evaluation showed that the new derivatives were active against macrolide-resistant clinical isolates of bacteria and mycoplasmas, and that they were resistant to hepatic esterase.
以2'-O-乙酰基-3'',4''-O-（二丁基锡）泰乐菌素为合成中间体，合成了4''-O-酰基-、4''-O-烷基-和4''-脱氧-泰乐菌素衍生物。体外生物学评价表明，这些新衍生物对耐大环内酯类临床分离细菌和支原体具有活性，并且对肝脏酯酶具有抗性。
