凝血因子 XIII Val34Leu 基因多态性与冠状动脉疾病的关联：一项荟萃分析。

Association of factor XIII Val34Leu polymorphism and coronary artery disease: A meta-analysis.

作者信息

Jung Jae Hyun, Song Gwan Gyu, Kim Jae-Hoon, Seo Young Ho, Choi Sung Jae

机构信息

Korea University College of Medicine, Seoul, Korea Department of Internal Medicine, Division of Rheumatology, Korea University Ansan Hospital, Ansan-si, Gyeonggi-do, Korea.

出版信息

Cardiol J. 2017;24(1):74-84. doi: 10.5603/CJ.a2016.0070. Epub 2016 Sep 26.

DOI:10.5603/CJ.a2016.0070

PMID:27665853

Abstract

BACKGROUND

Factor XIII plays an important role in the stabilization of the linkage between fibrins and in the pathophysiology of coronary artery disease (CAD). The association between factor XIII Val34Leu polymorphism and CAD risk remains controversial.

METHODS

We conducted a meta-analysis of 36 studies involving 26,940 cases and 34,694 controls. Subgroup analyses were performed with division of data into disease (myocardial infarction [MI], CAD without MI), age, and sex.

RESULTS

Factor XIII Val34Leu polymorphism was significantly associated with ove all CAD risk (odds ratio [OR] = 1.09, 95% confidence interval [CI] = 1.03-1.06, p = 0.004) and MI risk (OR = 1.15, 95% CI 1.07-1.25, p = 0.0003), but not with CAD without MI risk (OR = 1.00, 95% CI 0.87-1.15, p = 0.96). In the subgroup analysis by age and sex, there was no association between Val34Leu polymorphism and CAD.

CONCLUSIONS

This meta-analysis found that factor XIII Val34Leu polymorphism was associated with CAD risk, especially MI, but not with CAD without MI. In addition, age and sex did not affect the relationship between factor XIII Val34Leu polymorphism and CAD risk.

摘要

背景

凝血因子 XIII 在纤维蛋白间连接的稳定以及冠状动脉疾病（CAD）的病理生理学中起重要作用。凝血因子 XIII Val34Leu 多态性与 CAD 风险之间的关联仍存在争议。

方法

我们对 36 项研究进行了荟萃分析，涉及 26940 例病例和 34694 例对照。根据疾病（心肌梗死 [MI]、无 MI 的 CAD）、年龄和性别对数据进行分组，进行亚组分析。

结果

凝血因子 XIII Val34Leu 多态性与总体 CAD 风险（优势比 [OR] = 1.09，95% 置信区间 [CI] = 1.03 - 1.06，p = 0.004）和 MI 风险（OR = 1.15，95% CI 1.07 - 1.25，p = 0.0003）显著相关，但与无 MI 的 CAD 风险无关（OR = 1.00，95% CI 0.87 - 1.15，p = 0.96）。在按年龄和性别进行的亚组分析中，Val34Leu 多态性与 CAD 之间无关联。