Sacchetti Sara, Puricelli Chiara, Mennuni Marco, Zanotti Valentina, Giacomini Luca, Giordano Mara, Dianzani Umberto, Patti Giuseppe, Rolla Roberta
Clinical Chemistry Laboratory, "Maggiore della Carità" University Hospital, Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy.
Division of Cardiology, "Maggiore della Carità" University Hospital, Department of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy.
Int J Mol Sci. 2024 Feb 21;25(5):2523. doi: 10.3390/ijms25052523.
Thrombosis is a multifaceted process involving various molecular components, including the coagulation cascade, platelet activation, platelet-endothelial interaction, anticoagulant signaling pathways, inflammatory mediators, genetic factors and the involvement of various cells such as endothelial cells, platelets and leukocytes. A comprehensive understanding of the molecular signaling pathways and cell interactions that play a role in thrombosis is essential for the development of precise therapeutic strategies for the treatment and prevention of thrombotic diseases. Ongoing research in this field is constantly uncovering new molecular players and pathways that offer opportunities for more precise interventions in the clinical setting. These molecular insights into thrombosis form the basis for the development of targeted therapeutic approaches for the treatment and prevention of thrombotic disease. The aim of this review is to provide an overview of the pathogenesis of thrombosis and to explore new therapeutic options.
血栓形成是一个多方面的过程，涉及多种分子成分，包括凝血级联反应、血小板活化、血小板与内皮细胞的相互作用、抗凝信号通路、炎症介质、遗传因素以及各种细胞（如内皮细胞、血小板和白细胞）的参与。全面了解在血栓形成中起作用的分子信号通路和细胞相互作用，对于制定治疗和预防血栓性疾病的精确治疗策略至关重要。该领域正在进行的研究不断揭示新的分子参与者和通路，为临床环境中更精确的干预提供了机会。这些对血栓形成的分子见解构成了开发治疗和预防血栓性疾病的靶向治疗方法的基础。本综述的目的是概述血栓形成的发病机制，并探索新的治疗选择。
