系统性红斑狼疮中的周围神经病变：临床和电生理特性及其与疾病活动参数的关联

Peripheral Neuropathy in Systemic Lupus Erythematosus: Clinical and Electrophysiological Properties and their Association with Disease Activity Parameters.

作者信息

Saigal Renu, Bhargav Rajat, Goyal Laxmikant, Agrawal Abhishek, Mital Pradeep, Wadhwani Dileep

机构信息

Professor, Department of Medicine, In-charge Rheumatology Clinic, MG Medical College.

Senior Resident.

出版信息

J Assoc Physicians India. 2015 Dec;63(12):15-19.

PMID:27666898

Abstract

AIM

To study clinical and electrophysiological properties of peripheral neuropathy (PN) in systemic lupus erythematosus (SLE) and their association with disease activity parameters.

METHODS

A hospital-based observational study done among 50 SLE patients after informed consent. History and clinical examination including a detailed neurological examination was carried out. Blood and urine investigation were done and modified SLE disease activity index (SLEDAI)-2000 score was calculated.

RESULTS

PN was found in 18 out of 50 (36%) SLE cases as defined electrophysiologically, nine had clinical and nine had subclinical neuropathy. On nerve conduction studies (NCS) 17 patients had axonal pattern. There were significant difference for mean ESR in patients with neuropathy (64.17 ± 42.43 mm/1st hour) and without neuropathy (42.34 ± 27.68 mm/1st hour) (P 0.033) and for mean modified SLEDAI-2000 of patients with neuropathy (15.61 ± 10.09) and without neuropathy (6.84 ± 6.16) (P < 0.05).

CONCLUSIONS

The study suggests significant association of peripheral neuropathy in SLE patients with ESR, modified SLEDAI-2000, pyuria, pleurisy and leucopenia.

摘要

目的

研究系统性红斑狼疮（SLE）患者周围神经病变（PN）的临床和电生理特性及其与疾病活动参数的关联。

方法

在50例SLE患者签署知情同意书后进行一项基于医院的观察性研究。进行病史采集和临床检查，包括详细的神经系统检查。进行血液和尿液检查，并计算改良的SLE疾病活动指数（SLEDAI）-2000评分。

结果

在50例SLE病例中，经电生理定义发现18例（36%）存在PN，9例有临床神经病变，9例有亚临床神经病变。在神经传导研究（NCS）中，17例患者表现为轴索性模式。神经病变患者的平均血沉（ESR）（64.17±42.43mm/第1小时）与无神经病变患者（42.34±27.68mm/第1小时）之间存在显著差异（P = 0.033），神经病变患者的平均改良SLEDAI-2000（15.61±10.09）与无神经病变患者（6.84±6.16）之间也存在显著差异（P<0.05）。