Department of Neurology, Medikent Hospital, Kırklareli, Turkey.
Department of Internal Medicine, Medikent Hospital, Kırklareli, Turkey.
Adv Rheumatol. 2020 Jun 5;60(1):31. doi: 10.1186/s42358-020-00133-9.
Evaluating small nerve fibers in patients with systemic lupus erythematosus (SLE) using cutaneous silent period (CSP) and skin biopsy and assesssing the relationship between clinical signs, autoantibodies and neuropathic pain score.
OBJECTIVE - METHODS: Fifty one SLE patients and 46 healthy volunteers were included in this study. Nerve conduction studies and CSP were performed both on upper and lower limbs in subjects. Skin biopsy was performed and the number of epidermal nerve density and IL-6 staining were evaluated.
In SLE patients, CSP latencies were significantly prolonged both in lower and upper limbs and lower and upper extremity CSP durations were significantly shorter when compared to controls (p < 0.001). The number of epidermal nerve was significantly lower in SLE patients when compared to healthy controls (p < 0.001).
We detected marked small nerve fiber damage in both lower and upper limbs in SLE patients using CSP. Decreased epidermal nerve density also supports this finding.
使用皮肤静止期（CSP）和皮肤活检评估系统性红斑狼疮（SLE）患者的小神经纤维，并评估临床症状、自身抗体和神经病理性疼痛评分之间的关系。
目的-方法：本研究纳入了 51 例 SLE 患者和 46 名健康志愿者。对受试者的上下肢进行神经传导研究和 CSP。进行皮肤活检，并评估表皮神经密度和 IL-6 染色的数量。
与对照组相比，SLE 患者的 CSP 潜伏期在下肢和上肢以及下肢和上肢 CSP 持续时间均显著延长（p<0.001）。与健康对照组相比，SLE 患者的表皮神经数量显著减少（p<0.001）。
我们使用 CSP 检测到 SLE 患者的上下肢小神经纤维明显受损。表皮神经密度降低也支持这一发现。
