氨己烯酸对人体脑脊液氨基酸的药代动力学影响。

Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans.

作者信息

Ben-Menachem E

机构信息

Department of Neurology, University of Gothenburg, Sahlgren Hospital, Sweden.

出版信息

Epilepsia. 1989;30 Suppl 3:S12-4. doi: 10.1111/j.1528-1157.1989.tb05826.x.

DOI:10.1111/j.1528-1157.1989.tb05826.x

Abstract

A study was conducted to assess the impact of single dosing and different dosing intervals of vigabatrin [gamma vinyl GABA (GVG)] in 11 patients with drug-resistant complex partial seizures. Cerebrospinal fluid (CSF) concentrations of total GABA, free GABA, homocarnosine, homovanillic acid (HVA), GVG, and 5-hydroxyindolacetic acid were measured up to seven days after a single dose. GVG levels were maximal within 24 h, suggesting that GVG acts to inhibit GABA-transaminase, and may also increase biogenic amines.

摘要

一项研究旨在评估11例耐药性复杂部分性癫痫患者单次服用和不同给药间隔的氨己烯酸[γ-乙烯基γ-氨基丁酸（GVG）]的影响。在单次给药后长达7天的时间内，测量了脑脊液（CSF）中总γ-氨基丁酸（GABA）、游离GABA、高肌肽、高香草酸（HVA）、GVG和5-羟吲哚乙酸的浓度。GVG水平在24小时内达到最高，这表明GVG可抑制GABA转氨酶，并且还可能增加生物胺。

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