白藜芦醇在慢性疾病中的治疗潜力与分子靶点

Therapeutic Potential and Molecular Targets of Piceatannol in Chronic Diseases.

作者信息

Surh Young-Joon, Na Hye-Kyung

机构信息

Department of Molecular Medicine and Biopharmaceutical Sciences, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea.

Department of Food and Nutrition, College of Human Ecology, Sungshin Women's University, Seoul, 142-732, South Korea.

出版信息

Adv Exp Med Biol. 2016;928:185-211. doi: 10.1007/978-3-319-41334-1_9.

DOI:10.1007/978-3-319-41334-1_9

PMID:27671818

Abstract

Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene; PIC) is a naturally occurring stilbene present in diverse plant sources. PIC is a hydroxylated analog of resveratrol and produced from resveratrol by microsomal cytochrome P450 1A11/2 and 1B1 activities. Like resveratrol, PIC has a broad spectrum of health beneficial effects, many of which are attributable to its antioxidative and anti-inflammatory activities. PIC exerts anticarcinogenic effects by targeting specific proteins involved in regulating cancer cell proliferation, survival/death, invasion, metastasis, angiogenesis, etc. in tumor microenvironment. PIC also has other health promoting and disease preventing functions, such as anti-obese, antidiabetic, neuroptotective, cardioprotective, anti-allergic, anti-aging properties. This review outlines the principal biological activities of PIC and underlying mechanisms with special focus on intracellular signaling molecules/pathways involved.

摘要

白皮杉醇（3,3',4,5'-四羟基反式芪；PIC）是一种天然存在的芪类化合物，存在于多种植物来源中。PIC是白藜芦醇的羟基化类似物，由微粒体细胞色素P450 1A11/2和1B1的活性从白藜芦醇产生。与白藜芦醇一样，PIC具有广泛的有益健康作用，其中许多归因于其抗氧化和抗炎活性。PIC通过靶向参与调节肿瘤微环境中癌细胞增殖、存活/死亡、侵袭、转移、血管生成等的特定蛋白质发挥抗癌作用。PIC还具有其他促进健康和预防疾病的功能，如抗肥胖、抗糖尿病、神经保护、心脏保护、抗过敏、抗衰老特性。本综述概述了PIC的主要生物学活性及其潜在机制，特别关注所涉及的细胞内信号分子/途径。