Kumar Anand, Gangaiah Dharanesh, Torrelles Jordi B, Rajashekara Gireesh
Anand Kumar, Gireesh Rajashekara, 170 Food Animal Health Research Program and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Wooster, OH 44691, United States.
World J Gastroenterol. 2016 Sep 7;22(33):7402-14. doi: 10.3748/wjg.v22.i33.7402.
Campylobacter jejuni (C. jejuni), a Gram-negative microaerophilic bacterium, is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide. Despite its importance as a major foodborne pathogen, our understanding of the molecular mechanisms underlying C. jejuni stress survival and pathogenesis is limited. Inorganic polyphosphate (poly P) has been shown to play significant roles in bacterial resistance to stress and virulence in many pathogenic bacteria. C. jejuni contains the complete repertoire of enzymes required for poly P metabolism. Recent work in our laboratory and others have demonstrated that poly P controls a plethora of C. jejuni properties that impact its ability to survive in the environment as well as to colonize/infect mammalian hosts. This review article summarizes the current literature on the role of poly P in C. jejuni stress survival and virulence and discusses on how poly P-related enzymes can be exploited for therapeutic/prevention purposes. Additionally, the review article identifies potential areas for future investigation that would enhance our understanding of the role of poly P in C. jejuni and other bacteria, which ultimately would facilitate design of effective therapeutic/preventive strategies to reduce not only the burden of C. jejuni-caused foodborne infections but also of other bacterial infections in humans.
空肠弯曲菌（C. jejuni）是一种革兰氏阴性微需氧细菌，是全球人类细菌性食源性肠胃炎的主要病因。尽管它作为一种主要的食源性病原体很重要，但我们对空肠弯曲菌应激存活和致病的分子机制的了解仍然有限。无机多聚磷酸盐（多聚P）已被证明在许多致病细菌的应激抗性和毒力中发挥重要作用。空肠弯曲菌含有多聚P代谢所需的完整酶系。我们实验室和其他机构最近的研究表明，多聚P控制着大量影响空肠弯曲菌在环境中生存以及在哺乳动物宿主中定殖/感染能力的特性。这篇综述文章总结了关于多聚P在空肠弯曲菌应激存活和毒力中作用的当前文献，并讨论了如何利用与多聚P相关的酶进行治疗/预防。此外，这篇综述文章确定了未来研究的潜在领域，这些领域将加深我们对多聚P在空肠弯曲菌和其他细菌中作用的理解，最终将有助于设计有效的治疗/预防策略，不仅减轻空肠弯曲菌引起的食源性感染负担，还减轻人类其他细菌感染的负担。
