Grzybowski Andrzej, Sikorski Bartosz L, Ascaso Francisco J, Huerva Valentín
Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland; Department of Ophthalmology, Poznań City Hospital, Poznań, Poland.
Department of Ophthalmology, Nicolaus Copernicus University, Bydgoszcz, Poland.
Clin Interv Aging. 2016 Sep 9;11:1221-1229. doi: 10.2147/CIA.S111761. eCollection 2016.
Pseudophakic cystoid macular edema (PCME) is the most common complication of cataract surgery, leading in some cases to a decrease in vision. Although the pathogenesis of PCME is not completely understood, the contribution of postsurgical inflammation is generally accepted. Consequently, anti-inflammatory medicines, including steroids and nonsteroidal anti-inflammatory drugs, have been postulated as having a role in both the prophylaxis and treatment of PCME. However, the lack of a uniformly accepted PCME definition, conflicting data on some risk factors, and the scarcity of studies comparing the role of nonsteroidal anti-inflammatory drugs to steroids in PCME prevention make the problem of PCME one of the puzzles of ophthalmology. This paper presents an updated review on the pathogenesis, risk factors, and use of anti-inflammatory drugs in PCME that reflect current research and practice.
人工晶状体眼黄斑囊样水肿（PCME）是白内障手术最常见的并发症，在某些情况下会导致视力下降。尽管PCME的发病机制尚未完全明确，但术后炎症的作用已得到普遍认可。因此，包括类固醇和非甾体类抗炎药在内的抗炎药物被认为在PCME的预防和治疗中均发挥作用。然而，由于缺乏统一认可的PCME定义、一些危险因素的数据相互矛盾，以及比较非甾体类抗炎药与类固醇在PCME预防中作用的研究较少，使得PCME问题成为眼科领域的难题之一。本文对PCME的发病机制、危险因素以及抗炎药物的应用进行了最新综述，反映了当前的研究和实践情况。
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