Arrigo Rita, Failla Giuseppe, Scichilone Nicola, La Sala Alba, Galeone Carla, Battaglia Salvatore, Benfante Alida, Facciolongo Nicola
Dipartimento di Biomedicina e Medicina Specialistica, Sezione di Pneumologia, University of Palermo, Palermo, Italy.
Interventional Endoscopic Unit, ARNAS Ospedale Civico Di Cristina Benfratelli, Palermo, Italy.
Biomed Res Int. 2016;2016:9132198. doi: 10.1155/2016/9132198. Epub 2016 Sep 8.
There is limited information on the efficacy and safety of bronchial thermoplasty (BT) in . We evaluated the outcomes of the randomized clinical trials for BT in severe asthmatics, in whom the exclusion criteria were not strictly controlled. A case series of seven asthmatics (M/F: 4/3; age: 54.6 ± 2.9 years) is reported. Subjects had a statistically significant improvement in AQLQ (from a mean of 3.96 ± 1.1 to 4.5 ± 1.2 and 5.5 ± 0.6 after 6 and 12 months of treatment; = 0.0007) and in the ACQ score (from 2.77 ± 0.8 to 1.83 ± 1.2 and 1.5 ± 0.8 after 6 and 12 months; < 0.001). In the year after BT, severe exacerbations, salbutamol use, and OCS use were significantly lower compared with the 1-yr pretreatment period ( < 0.001). No ED visits and hospitalization occurred in the year after BT. No changes in functional parameters were recorded. Our investigation confirms the safety and efficacy of BT in severe asthmatics in settings.
关于支气管热成形术（BT）在……中的疗效和安全性的信息有限。我们评估了针对重度哮喘患者的BT随机临床试验结果，这些患者的排除标准未得到严格控制。报告了一组7例哮喘患者的病例系列（男/女：4/3；年龄：54.6±2.9岁）。治疗6个月和12个月后，受试者的哮喘生活质量问卷（AQLQ）有统计学显著改善（从平均3.96±1.1分别提高到4.5±1.2和5.5±0.6；P = 0.0007），哮喘控制问卷（ACQ）评分也有改善（6个月和12个月后分别从2.77±0.8降至1.83±1.2和1.5±0.8；P<0.001）。在BT后的一年中，与治疗前1年相比，严重发作、沙丁胺醇使用和口服糖皮质激素（OCS）使用显著减少（P<0.001）。BT后一年未发生急诊就诊和住院情况。未记录到功能参数的变化。我们的研究证实了BT在……环境下重度哮喘患者中的安全性和有效性。
