Rao G N, Piegorsch W W, Crawford D D, Edmondson J, Haseman J K
National Toxicology Program-Division of Toxicology Research and Testing, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Fundam Appl Toxicol. 1989 Jul;13(1):156-64. doi: 10.1016/0272-0590(89)90315-1.
Sendai virus (SV), mouse hepatitis virus (MHV), and pneumonia virus of mice (PVM) are common viral infections of mice. Influence of these viral infections on the prevalence of liver tumors, lung tumors, and lymphoma is of concern in chemical carcinogenicity studies. Body weight, survival, and tumor prevalence of B6C3F1 mice with and without viral infections in 33 male and 34 female untreated control groups and 32 male and 32 female low- and high-dose groups of 2-year chemical carcinogenicity studies were evaluated. In male mice, the SV infection was associated with significantly (p less than 0.05) higher survival of control, low-dose, and high-dose groups, and higher prevalence of liver tumors and lymphoma. The increases in tumor prevalence are possibly due to an increase in the survival of male mice that had SV infection. However, when interlaboratory variability and time-related effects were taken into account, the number of significant effects was consistent with the expected false-positive rate inherent to the statistical procedures. The MHV and PVM infections did not cause consistent changes in body weight, survival, and tumor prevalences in the control and chemical treatment groups of male mice. Viral infections did not cause consistent increases or decreases in body weight, survival, or tumor prevalence in the control and chemical treatment groups of female B6C3F1 mice.
仙台病毒（SV）、小鼠肝炎病毒（MHV）和小鼠肺炎病毒（PVM）是小鼠常见的病毒感染。在化学致癌性研究中，这些病毒感染对肝肿瘤、肺肿瘤和淋巴瘤患病率的影响备受关注。对33只雄性和34只雌性未处理对照组以及32只雄性和32只雌性低剂量组和高剂量组的B6C3F1小鼠在2年化学致癌性研究中有无病毒感染情况下的体重、存活率和肿瘤患病率进行了评估。在雄性小鼠中，SV感染与对照组、低剂量组和高剂量组显著更高的存活率（p小于0.05）以及更高的肝肿瘤和淋巴瘤患病率相关。肿瘤患病率的增加可能是由于感染SV的雄性小鼠存活率提高所致。然而，当考虑到实验室间变异性和时间相关效应时，显著效应的数量与统计程序固有的预期假阳性率一致。MHV和PVM感染在雄性小鼠的对照组和化学处理组中并未导致体重、存活率和肿瘤患病率出现一致变化。在雌性B6C3F1小鼠的对照组和化学处理组中，病毒感染也未导致体重、存活率或肿瘤患病率出现一致的增加或减少。
