Mansi M L
J Am Osteopath Assoc. 1989 Jul;89(7):929-32.
Several decades ago, diethylstilbestrol (DES) was prescribed to support the pregnancy of women who were diabetic, who had had consecutive abortions, or who were threatening to abort. The use of this estrogen substitute to support human gestation had ceased by the 1960s. In 1971, the first report was published in which DES exposure was linked with clear cell carcinoma of the vagina and cervix. Since then, many other documentations have been published on upper genital tract anomalies, poor reproductive performance, and the high incidence of fetal wastage in DES-exposed women. The author describes a case of clear cell carcinoma of the kidney in an 18-year-old pregnant woman with a prior history of vaginal adenosis who had been exposed to DES in utero.
几十年前，己烯雌酚（DES）被用于治疗患有糖尿病、有连续流产史或有流产风险的孕妇，以维持她们的妊娠。到20世纪60年代，这种雌激素替代品已不再用于维持人类妊娠。1971年，首篇关于DES暴露与阴道和宫颈透明细胞癌相关的报告发表。此后，又有许多文献报道了DES暴露女性的上生殖道畸形、生殖功能不佳及胎儿流失率高等情况。作者描述了一例18岁孕妇患肾透明细胞癌的病例，该孕妇既往有阴道腺病病史，且在子宫内曾接触过DES。
