Department of Molecular Biology, University of Salzburg , Billrothstrasse 11, 5020 Salzburg, Austria.
Institut für Organische Chemie, Universität Regensburg , Universitätsstrasse 31, 93053 Regensburg, Germany.
J Org Chem. 2016 Nov 4;81(21):10109-10125. doi: 10.1021/acs.joc.6b02034. Epub 2016 Oct 10.
The synthesis of heterocycles is arguably one of the oldest and at the same time one of the youngest disciplines of organic chemistry. Groundbreaking principles to form heterocycles, mainly by condensation reactions, were recognized in the beginning of the 19th century, and many of the classical reactions discovered at that time are still of great value today. In the 21st century, the wealth of synthetic methodology toward heterocycles is overwhelming, and catalysis, in particular, as one of the cornerstones of green and sustainable chemistry has contributed in a major way to these developments. This perspective tries the impossible by discussing some recent advances in the construction of heterocycles, focusing on catalytic methodology. We are aware that we do not come close to giving adequate credit to the great creativity of chemists in the field.
杂环化合物的合成就其本身而言，既是有机化学最古老的领域之一，也是最年轻的领域之一。杂环化合物的开创性形成原则，主要通过缩合反应，在 19 世纪初就已经被认识到，并且当时发现的许多经典反应至今仍具有重要价值。在 21 世纪，杂环化合物的合成方法学非常丰富，而催化作为绿色和可持续化学的基石之一，对这些发展做出了重大贡献。本文通过讨论杂环化合物构建方面的一些最新进展，重点介绍催化方法学，试图探讨这一不可能的任务。我们意识到，我们远没有充分肯定该领域化学家长久以来的伟大创造力。
