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[中轴型脊柱关节炎的管理]

[Management of axial spondyloarthritis].

作者信息

Kiltz U, Baraliakos X, Braun J

机构信息

Rheumazentrum Ruhrgebiet, Claudiusstr. 45, 44649, Herne, Deutschland.

出版信息

Internist (Berl). 2016 Nov;57(11):1060-1068. doi: 10.1007/s00108-016-0140-9.

DOI:10.1007/s00108-016-0140-9
PMID:27680737
Abstract

The term spondyloarthritis (SpA) is now increasingly used to classify and diagnose patients who are characterized by inflammation in the axial skeleton and peripheral manifestations (arthritis and enthesitis). The management of SpA should be tailored according to the current manifestations of the disease, the disease activity and functional impairment. The current article focuses on diagnosis and therapy in patients with axial SpA. Diagnostic procedures are discussed in light of diagnostic utility and feasibility in daily routine care. Cornerstones of treatment in patients with axial SpA are a combination of regular exercise and pharmacological treatment options aiming at anti-inflammatory strategies.

摘要

术语“脊柱关节炎(SpA)”如今越来越多地用于对以中轴骨骼炎症和外周表现(关节炎和附着点炎)为特征的患者进行分类和诊断。SpA的管理应根据疾病的当前表现、疾病活动度和功能损害进行调整。本文重点关注中轴型SpA患者的诊断和治疗。根据日常护理中的诊断效用和可行性对诊断程序进行了讨论。中轴型SpA患者治疗的基石是定期锻炼和旨在抗炎策略的药物治疗方案相结合。

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[Management of axial spondyloarthritis].[中轴型脊柱关节炎的管理]
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2
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本文引用的文献

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Anti-TNF discontinuation and tapering strategies in patients with axial spondyloarthritis: a systematic literature review.中轴型脊柱关节炎患者抗TNF停药及减量策略:一项系统文献综述
Rheumatology (Oxford). 2016 Jul;55(7):1188-94. doi: 10.1093/rheumatology/kew033. Epub 2016 Mar 21.
2
Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.司库奇尤单抗,一种白细胞介素-17A 抑制剂,治疗强直性脊柱炎。
N Engl J Med. 2015 Dec 24;373(26):2534-48. doi: 10.1056/NEJMoa1505066.
3
Effect of continuous versus on-demand treatment of ankylosing spondylitis with diclofenac over 2 years on radiographic progression of the spine: results from a randomised multicentre trial (ENRADAS).
双氯芬酸治疗强直性脊柱炎连续与按需治疗 2 年对脊柱放射学进展的影响:一项随机多中心试验(ENRADAS)的结果。
Ann Rheum Dis. 2016 Aug;75(8):1438-43. doi: 10.1136/annrheumdis-2015-207897. Epub 2015 Aug 4.
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TNF-alpha inhibitors for ankylosing spondylitis.用于强直性脊柱炎的肿瘤坏死因子-α抑制剂
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Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS.强直性脊柱炎关节外表现的存在及发展相关特征:来自OASIS研究的12年结果
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[German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew's disease and early forms: 8.6 Invasive therapy].[德国风湿病学会关于包括贝赫切特病和早期形式的轴向脊柱关节炎的S3指南:8.6侵入性治疗]
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7
[German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew's disease and early forms: 8.4 Pharmaceutical therapy, 8.5 Evaluation of therapy success of pharmaceutical measures].[德国风湿病学会关于包括贝赫切特病和早期形式的轴性脊柱关节炎的S3指南:8.4药物治疗,8.5药物治疗措施的疗效评估]
Z Rheumatol. 2014 Sep;73 Suppl 2:78-96. doi: 10.1007/s00393-014-1443-7.
8
[German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew's disease and early forms: 8.3 Nonpharmaceutical therapeutic measures].[德国风湿病学会关于包括贝赫切特病和早期形式在内的轴向型脊柱关节炎的S3指南:8.3非药物治疗措施]
Z Rheumatol. 2014 Sep;73 Suppl 2:71-7. doi: 10.1007/s00393-014-1442-8.
9
[German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew's disease and early forms: Editorial].[德国风湿病学会关于包括贝赫切特病和早期形式的轴性脊柱关节炎的S3指南:编者按]
Z Rheumatol. 2014 Sep;73 Suppl 2:20-2. doi: 10.1007/s00393-014-1425-9.
10
Reference intervals of spinal mobility measures in normal individuals: the MOBILITY study.正常个体脊柱活动度测量的参考区间:MOBILITY 研究。
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