Zhang Liya, Huang Zhijian, Tang Jihong, Li Yan
a Department of Neurology , Soochow University Affiliated Children's Hospital , Suzhou , China.
b Department of Burn and Plastic Surgery , Soochow University Affiliated Children's Hospital , Suzhou , China.
Int J Neurosci. 2017 Sep;127(9):745-751. doi: 10.1080/00207454.2016.1243105. Epub 2016 Oct 19.
To assess the recurrence rate after the first spontaneous epileptic seizure in pediatric patients, and determine the related risk factors.
Data from 190 infants (aged between one month and three years) admitted after first spontaneous epileptic seizure to Soochow University Affiliated Children's Hospital between April 2009 and April 2011 were retrospectively analyzed; patients were followed up until April 2014. The recurrence rate and risk factors of recurrence were analyzed based on central nervous system imaging data (computed tomography or magnetic resonance imaging), electroencephalogram (EEG) and developmental quotient assessment.
Of the 190 infants, 11 cases (5.79%) were lost to follow-up. The cumulative recurrence rate of spontaneous epileptic seizure after five years was 52%. A total of 82% recurrence cases occurred within the first year. Age > 24 months (odds ratio (OR) = 0.498༌95% confidence interval (CI): 0.285-0.869) was an independent protective factor, while symptomatic seizure (OR = 1.624, 95% CI: 1.020-2.587), seizure during sleep (OR = 2.779, 95% CI: 1.757-4.397) and epileptic discharge in EEG (OR=3.269, 95% CI: 2.049-5.217) were independent risk factors.
Recurrence rate is high in infants after the first spontaneous epileptic seizure, and recurrence is more likely to occur within one year.
评估小儿患者首次自发性癫痫发作后的复发率，并确定相关危险因素。
回顾性分析2009年4月至2011年4月间苏州大学附属儿童医院收治的190例首次自发性癫痫发作后的婴儿（年龄在1个月至3岁之间）的数据；对患者进行随访至2014年4月。基于中枢神经系统影像学数据（计算机断层扫描或磁共振成像）、脑电图（EEG）和发育商评估分析复发率及复发危险因素。
190例婴儿中，11例（5.79%）失访。5年后自发性癫痫发作的累积复发率为52%。共82%的复发病例发生在第一年内。年龄>24个月（比值比（OR）=0.498，95%置信区间（CI）：0.285 - 0.869）是独立保护因素，而症状性发作（OR = 1.624，95% CI：1.020 - 2.587）、睡眠中发作（OR = 2.779，95% CI：1.757 - 4.397）和脑电图癫痫放电（OR = 3.269，95% CI：2.049 - 5.217）是独立危险因素。
婴儿首次自发性癫痫发作后复发率高，且复发多在1年内发生。
