Lagarde A, Kerebel L M, Kerebel B
Unité INSERM 225, Faculté de chirurgie dentaire, Nantes.
J Biol Buccale. 1989 Jun;17(2):109-14.
Two premolars removed from a 14 year old girl, with suspicion of pseudohypoparathyroidism (PHP) have been studied, using several of the correlated techniques applied to the study of calcified tissues (light microscopy, microradiography and scanning electron microscopy). Enamel gross and micro hypoplasia, hypomineralization of the enamel surface and dentin hypocalcification were similar to dental abnormalities observed in pseudohypoparathyroidism. Microradiography showed for the first time calcifications present in blood vessels of the dental pulp. Light microscopy and SEM revealed dystrophic globular calcifications within enamel hypoplastic pits. Cemental changes consisting of hypoplasia, aplasia, localized hyperplasia and cementicules were described for the first time. It is suggested that enamel, dentine and pulp abnormalities observed in the present case might be pathognomonic of PHP.
对一名14岁疑似假性甲状旁腺功能减退症（PHP）女孩拔除的两颗前磨牙，运用了几种用于钙化组织研究的相关技术（光学显微镜、显微放射摄影和扫描电子显微镜）进行研究。牙釉质肉眼可见的和微观的发育不全、牙釉质表面矿化不足以及牙本质钙化不全，均与假性甲状旁腺功能减退症中观察到的牙齿异常相似。显微放射摄影首次显示牙髓血管中有钙化现象。光学显微镜和扫描电子显微镜显示在牙釉质发育不全的凹坑内有营养不良性球状钙化。首次描述了牙骨质的变化，包括发育不全、发育不全、局部增生和牙骨质小体。提示本病例中观察到的牙釉质、牙本质和牙髓异常可能是假性甲状旁腺功能减退症的特征性表现。
