National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain.
Consortium for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
J Adv Nurs. 2017 Mar;73(3):688-699. doi: 10.1111/jan.13170. Epub 2016 Oct 17.
To assess the association between baseline urinary incontinence and long-term, all-cause mortality.
Urinary incontinence is a common disorder among older institutionalised adults, with important consequences for morbidity and quality of life. Moreover, while it is a consistent mortality marker, the extent to which this association might be causal remains controversial.
A cohort study.
We conducted a mortality follow-up study on a cohort of 675 nursing-home residents in the city of Madrid (Spain), from their 1998-1999 baseline interviews to September 2013. Study subjects or their caregivers were asked whether the resident had experienced any involuntary leakage of urine in the preceding 14 days, with subjects being subsequently defined as continent, mildly incontinent, or severely incontinent. Hazard ratios for all-cause mortality were estimated using Cox proportional hazards models.
After a 4061 person-year follow-up (median/maximum of 4·6/15·2 years), 576 participants had died. In fully-adjusted models, urinary incontinence was associated with a 24 per cent increased risk of all-cause mortality. There was a graded relationship across severity levels, with hazard ratios 7% higher for mild and 44% higher for severe incontinence as compared with the continent group. The adjusted mortality fraction attributable to urinary incontinence was 11 per cent.
It would appear that urinary incontinence is not only a marker but also a real determinant of survival in the institutionalized population. This finding, which seems plausible in a population of frail older adults, warrants further research into mechanisms that could help to elucidate this hypothesis.
评估基线尿失禁与长期全因死亡率之间的关联。
尿失禁是老年住院患者中常见的疾病,对发病率和生活质量有重要影响。此外,尽管它是一个一致的死亡标志物,但这种关联是否具有因果关系仍存在争议。
队列研究。
我们对马德里市的 675 名养老院居民进行了一项死亡率随访研究,随访时间从他们 1998-1999 年的基线访谈到 2013 年 9 月。研究对象或其照顾者被问及居民在过去 14 天内是否经历过任何无意识的尿液泄漏,随后将研究对象定义为无尿失禁、轻度尿失禁或重度尿失禁。使用 Cox 比例风险模型估计全因死亡率的危险比。
在 4061 人年的随访(中位数/最大值为 4.6/15.2 年)后,有 576 名参与者死亡。在完全调整的模型中,尿失禁与全因死亡率增加 24%相关。在严重程度水平上存在分级关系,与无尿失禁组相比,轻度尿失禁的危险比增加 7%,重度尿失禁的危险比增加 44%。尿失禁归因于死亡率的调整分数为 11%。
尿失禁似乎不仅是一个标志物,而且是住院人群生存的一个真正决定因素。这一发现在体弱的老年人群中似乎是合理的,需要进一步研究机制,以帮助阐明这一假设。