银屑病关节炎患者银屑病斑块中的S100A8/A9
S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis.
作者信息
Chimenti Maria Sole, Triggianese Paola, Botti Elisabetta, Narcisi Alessandra, Conigliaro Paola, Giunta Alessandro, Teoli Miriam, Perricone Roberto, Costanzo Antonio
机构信息
Rheumatology, Allergology and Clinical Immunology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy
Rheumatology, Allergology and Clinical Immunology, Department of Systemic Medicine, University of Rome "Tor Vergata", Rome, Italy.
出版信息
J Int Med Res. 2016 Sep;44(1 suppl):33-37. doi: 10.1177/0300060515598900.
Abstract
OBJECTIVE
To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis.
METHODS
Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and semiquantitative polymerase chain reaction.
RESULTS
The study included biopsies from nine patients with psoriatic arthritis and nine control subjects. S100A8 and S100A9 were present at visibly higher levels in psoriatic plaques compared with normal skin samples. S100A8 and S100A9 RNA levels were significantly higher in the peripheral region of plaques compared with the central region.
CONCLUSION
Both S100A8 and S100A9 may represent good therapeutic targets in psoriasis and psoriatic arthritis.
摘要
目的
评估银屑病关节炎患者皮肤中钙结合蛋白S100A8和S100A9的水平。
方法
从银屑病关节炎患者和健康对照者身上获取皮肤打孔活检样本。通过免疫组织化学和半定量聚合酶链反应对S100A8/A9进行半定量分析。
结果
该研究纳入了9例银屑病关节炎患者和9例对照者的活检样本。与正常皮肤样本相比，银屑病斑块中S100A8和S100A9的水平明显更高。与斑块中央区域相比，斑块周边区域的S100A8和S100A9 RNA水平显著更高。
结论
S100A捌和S100A9可能都是银屑病和银屑病关节炎良好的治疗靶点。
相似文献
1
S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis.银屑病关节炎患者银屑病斑块中的S100A8/A9
J Int Med Res. 2016 Sep;44(1 suppl):33-37. doi: 10.1177/0300060515598900.
2
S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin.S100A8 和 S100A9 是表皮和真皮相互交流的信息传递者，调节人类皮肤的银屑病微环境。
Biochem Biophys Res Commun. 2012 Jul 13;423(4):647-53. doi: 10.1016/j.bbrc.2012.05.162. Epub 2012 Jun 7.
3
Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis.血清中钙结合蛋白S100A8和S100A9水平升高反映了银屑病的疾病活动度以及角质形成细胞的异常分化。
Br J Dermatol. 2006 Jul;155(1):62-6. doi: 10.1111/j.1365-2133.2006.07198.x.
4
Biological therapy downregulates the heterodimer S100A8/A9 (calprotectin) expression in psoriatic patients.生物疗法可下调银屑病患者异二聚体 S100A8/A9（钙卫蛋白）的表达。
Inflamm Res. 2018 Jul;67(7):609-616. doi: 10.1007/s00011-018-1147-6. Epub 2018 Mar 31.
5
Stratum corneum levels of calprotectin proteins S100A8/A9 correlate with disease activity in psoriasis patients.角质层中钙卫蛋白 S100A8/A9 水平与银屑病患者的疾病活动度相关。
J Dermatol. 2021 Oct;48(10):1518-1525. doi: 10.1111/1346-8138.16032. Epub 2021 Jun 24.
6
Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis.髓系相关蛋白S100A8/S100A9在抗原诱导的关节炎中调节关节炎症和软骨破坏。
Ann Rheum Dis. 2008 Dec;67(12):1750-8. doi: 10.1136/ard.2007.077800. Epub 2007 Nov 30.
7
S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes.S100A8/A9，正常人角质形成细胞正反馈生长刺激的关键介质。
J Cell Biochem. 2008 May 15;104(2):453-64. doi: 10.1002/jcb.21639.
8
Comparison of mRNA, Protein, and Urinary Nucleic Acid Levels of S100A8 and S100A9 between Prostate Cancer and BPH.前列腺癌与良性前列腺增生症之间S100A8和S100A9的mRNA、蛋白质及尿核酸水平比较
Ann Surg Oncol. 2015 Jul;22(7):2439-45. doi: 10.1245/s10434-014-4194-4. Epub 2014 Oct 28.
9
S100A8/A9 is associated with estrogen receptor loss in breast cancer.S100A8/A9与乳腺癌中的雌激素受体缺失有关。
Oncol Lett. 2016 Mar;11(3):1936-1942. doi: 10.3892/ol.2016.4134. Epub 2016 Jan 20.
10
S100A9 has a protective role in inflammation-induced skin carcinogenesis.S100A9在炎症诱导的皮肤癌发生过程中具有保护作用。
Int J Cancer. 2014 Aug 15;135(4):798-808. doi: 10.1002/ijc.28725. Epub 2014 Jan 28.
引用本文的文献
1
Characteristics and multi-omics analysis of spontaneous spondyloarthritis in non-human primates: Case report.非人灵长类动物自发性脊柱关节炎的特征及多组学分析：病例报告
Heliyon. 2025 Jan 8;11(2):e41706. doi: 10.1016/j.heliyon.2025.e41706. eCollection 2025 Jan 30.
2
Identification of neutrophil extracellular traps genes as potential biomarkers in psoriasis based on bioinformatics analysis.基于生物信息学分析鉴定中性粒细胞胞外诱捕网基因作为银屑病的潜在生物标志物。
Sci Rep. 2024 Oct 11;14(1):23848. doi: 10.1038/s41598-024-75069-x.
3
Environmental and Genetic Determinants of Ankylosing Spondylitis.环境与遗传因素与强直性脊柱炎的相关性。
Int J Mol Sci. 2024 Jul 17;25(14):7814. doi: 10.3390/ijms25147814.
4
S100A8 alarmin supports IL-6 and metalloproteinase-9 production by fibroblasts in the synovial microenvironment of peripheral spondyloarthritis.S100A8 警报素可支持周围型脊柱关节炎滑膜微环境中成纤维细胞产生白细胞介素 6 和金属蛋白酶 9。
Front Immunol. 2023 Jan 9;13:1077914. doi: 10.3389/fimmu.2022.1077914. eCollection 2022.
5
Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease.角质形成细胞衍生的S100A9调节中性粒细胞浸润并影响银屑病样皮肤和关节疾病。
Ann Rheum Dis. 2022 Sep 12;81(10):1400-1408. doi: 10.1136/annrheumdis-2022-222229.
6
Clinical parameters and biological markers associated with acute severe ocular complications in Stevens-Johnson syndrome and toxic epidermal necrolysis.与 Stevens-Johnson 综合征和中毒性表皮坏死松解症急性严重眼部并发症相关的临床参数和生物标志物。
Sci Rep. 2021 Oct 12;11(1):20275. doi: 10.1038/s41598-021-99370-1.
7
Calprotectin: from biomarker to biological function.钙卫蛋白：从生物标志物到生物学功能。
Gut. 2021 Oct;70(10):1978-1988. doi: 10.1136/gutjnl-2021-324855. Epub 2021 Jun 18.
8
Interleukin 17 Promotes Expression of Alarmins S100A8 and S100A9 During the Inflammatory Response of Keratinocytes.白细胞介素 17 在角质形成细胞的炎症反应中促进警报素 S100A8 和 S100A9 的表达。
Front Immunol. 2021 Feb 12;11:599947. doi: 10.3389/fimmu.2020.599947. eCollection 2020.
9
Differentiating Staphylococcus infection-associated glomerulonephritis and primary IgA nephropathy: a mass spectrometry-based exploratory study.基于质谱的探索性研究：鉴别金黄色葡萄球菌感染相关性肾小球肾炎和原发性 IgA 肾病。
Sci Rep. 2020 Oct 14;10(1):17179. doi: 10.1038/s41598-020-73847-x.
10
Gene expression profile analysis of ileum transcriptomes in pigs fed Gelsemium elegans plants.猪回肠转录组基因表达谱分析在服用钩吻植物。
Sci Rep. 2019 Oct 31;9(1):15756. doi: 10.1038/s41598-019-52374-4.
本文引用的文献
1
CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin.CCL7 促成了银屑病皮损皮肤中依赖肿瘤坏死因子-α 的炎症反应。
Exp Dermatol. 2015 Jul;24(7):522-8. doi: 10.1111/exd.12709. Epub 2015 May 4.
2
S100A8-S100A9 protein complex mediates psoriasis by regulating the expression of complement factor C3.S100A8-S100A9 蛋白复合物通过调节补体因子 C3 的表达来介导银屑病。
Immunity. 2013 Dec 12;39(6):1171-81. doi: 10.1016/j.immuni.2013.11.011.
3
Immunomodulation in psoriatic arthritis: focus on cellular and molecular pathways.银屑病关节炎的免疫调节：聚焦于细胞和分子途径。
Autoimmun Rev. 2013 Mar;12(5):599-606. doi: 10.1016/j.autrev.2012.10.002. Epub 2012 Nov 24.
4
Microarray analyses of peripheral blood cells identifies unique gene expression signature in psoriatic arthritis.外周血细胞的微阵列分析确定了银屑病关节炎中独特的基因表达特征。
Mol Med. 2005 Jan-Dec;11(1-12):21-9. doi: 10.2119/2006-00003.Gulko.
5
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins.由Jun蛋白诱导性表皮缺失引起的银屑病样皮肤病和关节炎。
Nature. 2005 Sep 15;437(7057):369-75. doi: 10.1038/nature03963.
6
Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide.S100A8和S100A9的阻断可抑制中性粒细胞对脂多糖的迁移反应。
J Immunol. 2003 Sep 1;171(5):2602-9. doi: 10.4049/jimmunol.171.5.2602.
7
Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules.吞噬细胞特异性S100蛋白：一组新型促炎分子。
Trends Immunol. 2003 Apr;24(4):155-8. doi: 10.1016/s1471-4906(03)00062-0.
8
Reduced synovial membrane macrophage numbers, ELAM-1 expression, and lining layer hyperplasia in psoriatic arthritis as compared with rheumatoid arthritis.与类风湿关节炎相比，银屑病关节炎患者滑膜巨噬细胞数量减少、ELAM-1表达降低以及衬里层增生减少。
Arthritis Rheum. 1993 Jul;36(7):893-900. doi: 10.1002/art.1780360705.
9
Severe psoriasis--oral therapy with a new retinoid.重度银屑病——一种新型维甲酸的口服治疗
Dermatologica. 1978;157(4):238-44. doi: 10.1159/000250839.
Zotero 插件