Jiao Mingke, Lou Lin, Jiao Lin, Hu Jie, Zhang Peng, Wang Zhongming, Xu Wenjuan, Geng Xiliang, Song Hongping
The Department of Medical Engineering, General Hospital of Xinjiang Military Region, Urumchi.
The Department of Echocardiography, Affiliated Traditional Chinese Medicine Hospital, Xinjiang Medical University, Urumqi, and.
Wound Repair Regen. 2016 Nov;24(6):1015-1022. doi: 10.1111/wrr.12487. Epub 2016 Oct 12.
Plateau frostbite (PF) treatments have remained a clinical challenge because this condition injures tissues in deep layers and affected tissues exhibit unique pathological characteristics. For instance, low-frequency pulsed electromagnetic field (PEMF) can affect tissue restoration and penetrate tissues. Therefore, the effect of PEMF on PF healing should be investigated. This study aimed to evaluate the effects of low-frequency PEMF on PF healing systematically. Ninety-six Sprague-Dawley rats were randomly and equally divided into three groups: normal control, partial thickness plateau frostbite (PTPF), and PTPF with low-frequency PEMF exposure (PTPF + PEMF). PTPF wounds were induced in the dorsum of the rats. The PTPF + PEMF group was exposed to low-frequency PEMF daily. During PF healing, wound microcirculation in each group was monitored through contrast ultrasonography. Wound appearance, histological observation, and wound tensile strength were also evaluated. Results showed that the rate of the microcirculation restoration of the PTPF + PEMF group was nearly 25% faster than that of the PTPF group, and wound appearance suggested that the healing of the PTPF group was slower than that of the PTPF + PEMF group. Histological observation revealed that PEMF accelerated the growth of different deep tissues, as confirmed by tensile strength examination. Low-frequency PEMF could penetrate PF tissues, promote their restoration, and provide a beneficial effect on PF healing. Therefore, this technique may be a potential alternative to treat PF.
高原冻伤（PF）的治疗一直是一项临床挑战，因为这种情况会损伤深层组织，且受影响的组织呈现出独特的病理特征。例如，低频脉冲电磁场（PEMF）可以影响组织修复并穿透组织。因此，应研究PEMF对PF愈合的影响。本研究旨在系统评估低频PEMF对PF愈合的影响。将96只Sprague-Dawley大鼠随机等分为三组：正常对照组、部分厚度高原冻伤组（PTPF）和低频PEMF暴露的PTPF组（PTPF + PEMF）。在大鼠背部诱导产生PTPF伤口。PTPF + PEMF组每天接受低频PEMF照射。在PF愈合过程中，通过超声造影监测每组伤口的微循环情况。还评估了伤口外观、组织学观察结果和伤口抗张强度。结果显示，PTPF + PEMF组的微循环恢复速度比PTPF组快近25%，伤口外观表明PTPF组的愈合速度比PTPF + PEMF组慢。组织学观察显示，PEMF促进了不同深层组织的生长，抗张强度检查证实了这一点。低频PEMF可以穿透PF组织，促进其修复，并对PF愈合产生有益影响。因此，这项技术可能是治疗PF的一种潜在替代方法。
